GAD65 Recombinant Antibody [PSH06-80] - Chicken IgY (Chimeric) - BSA and Azide free

Function

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.

Background References

1. Budhram A et al. Clinical spectrum of high-titre GAD65 antibodies. J Neurol Neurosurg Psychiatry. 2021 Feb

2. Budhram A et al. Positive Predictive Value of Anti-GAD65 ELISA Cut-Offs for Neurological Autoimmunity. Can J Neurol Sci. 2023 Sep

Subcellular Location

Cytoplasm, cytosol, Cytoplasmic vesicle, Presynaptic cell membrane, Golgi apparatus membrane.

UNIPROT

SwissProt: P48320 Mouse

SwissProt: Q05683 Rat

Synonyms