hSET1/SET1 Recombinant Rabbit Monoclonal Antibody [PH00-01] (HA721224)

UNIPROT #

O15047

PROTEIN NAME

hSET1/SET1

SYNONYMS

Histone-lysine N-methyltransferase SETD1A antibody;hSET1A antibody;KMT2F antibody;Lysine N methyltransferase 2F antibody;Lysine N-methyltransferase 2F antibody;SET domain containing 1A antibody;SET domain containing protein 1A antibody;SET domain-containing protein 1A antibody;SET1 antibody;Set1 Ash2 histone methyltransferase complex subunit SET1 antibody;Set1/Ash2 histone methyltransferase complex subunit SET1 antibody;SET1A antibody;SET1A_HUMAN antibody;SETD1A antibody

SUBCELLULAR LOCATION

Chromosome, Nucleus

FUNCTION

Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place. Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis. Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation. Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated.