PTGR1 Recombinant Rabbit Monoclonal Antibody [PSH02-12] (HA721771)

UNIPROT #

Q14914

PROTEIN NAME

PTGR1

SYNONYMS

15-oxoprostaglandin 13-reductase antibody;FLJ99229 antibody;leukotriene B4 12-hydroxydehydrogenase antibody;LTB4DH antibody;MGC34943 antibody;NADP-dependent leukotriene B4 12-hydroxydehydrogenase antibody;PGR1 antibody;PRG-1 antibody;Prostaglandin reductase 1 antibody;Ptgr1 antibody;PTGR1_HUMAN antibody;RP11-16L21.1 antibody;ZADH3 antibody;zinc binding alcohol dehydrogenase domain containing 3 antibody

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX). atalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha. Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites. Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site. May play a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one (PubMed:25619643). May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles.