Phospho-Tau (S404) Recombinant Rabbit Monoclonal Antibody [JE47-88] (HA721801)

UNIPROT #

P10636-8

PROTEIN NAME

Phospho-Tau (S404)

SYNONYMS

AI413597 antibody;AW045860 antibody;DDPAC antibody;FLJ31424 antibody;FTDP 17 antibody;G protein beta1/gamma2 subunit interacting factor 1 antibody;MAPT antibody;MAPTL antibody;MGC134287 antibody;MGC138549 antibody;MGC156663 antibody;Microtubule associated protein tau antibody;Microtubule associated protein tau isoform 4 antibody;Microtubule-associated protein tau antibody;MSTD antibody;Mtapt antibody;MTBT1 antibody;MTBT2 antibody;Neurofibrillary tangle protein antibody;Paired helical filament tau antibody;Paired helical filament-tau antibody;PHF tau antibody;PHF-tau antibody;PPND antibody;PPP1R103 antibody;Protein phosphatase 1, regulatory subunit 103 antibody;pTau antibody;RNPTAU antibody;TAU antibody;TAU_HUMAN antibody;Tauopathy and respiratory failure antibody;Tauopathy and respiratory failure, included antibody

SUBCELLULAR LOCATION

Cytoplasm, cytosol, Cell membrane, cytoskeleton, Cell projection, axon, dendrite, Secreted.

FUNCTION

The tau proteins (abbreviated from tubulin associated unit are a group of six highly soluble protein isoforms produced by alternative splicing from the gene MAPT (microtubule-associated protein tau). They have roles primarily in maintaining the stability of microtubules in axons and are abundant in the neurons of the central nervous system (CNS), where the cerebral cortex has the highest abundance. They are less common elsewhere but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. Pathologies and dementias of the nervous system such as Alzheimer's disease and Parkinson's disease are associated with tau proteins that have become hyperphosphorylated insoluble aggregates called neurofibrillary tangles. The tau proteins were identified in 1975 as heat-stable proteins essential for microtubule assembly, and since then they have been characterized as intrinsically disordered proteins.