beta Amyloid 1-40 Recombinant Rabbit Monoclonal Antibody [PSH05-86] (HA722485)

UNIPROT #

P05067

PROTEIN NAME

beta Amyloid 1-40

SYNONYMS

A4 antibody;A4_HUMAN antibody;AAA antibody;ABETA antibody;ABPP antibody;AICD-50 antibody;AICD-57 antibody;AICD-59 antibody;AID(50) antibody;AID(57) antibody;AID(59) antibody;Alzheimer disease amyloid protein antibody;Amyloid intracellular domain 50 antibody;Amyloid intracellular domain 57 antibody;Amyloid intracellular domain 59 antibody;APP antibody;APPI antibody;Beta amyloid protein 42 antibody;Beta APP42 antibody;Beta-APP40 antibody;Beta-APP42 antibody;C31 antibody;Cerebral vascular amyloid peptide antibody;CVAP antibody;Gamma-CTF(50) antibody;Gamma-CTF(57) antibody;Gamma-CTF(59) antibody;PN-II antibody;PreA4 antibody;Protease nexin-II antibody;S-APP-alpha antibody;S-APP-beta antibody

SUBCELLULAR LOCATION

Cell membrane, Membrane, Perikaryon, Cell projection, growth cone, Membrane, clathrin-coated pit, Early endosome, Cytoplasmic vesicle.

FUNCTION

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.