LSD2 / AOF1 Recombinant Rabbit Monoclonal Antibody [PSH06-18] (HA722515)

UNIPROT #

Q8NB78

PROTEIN NAME

LSD2 / AOF1

SYNONYMS

amine oxidase (flavin containing) domain 1 antibody;amine oxidase, flavin containing 1 antibody;AOF1 antibody;bA204B7.3 antibody;C6orf193 antibody;dJ298J15.2 antibody;Flavin-containing amine oxidase domain-containing protein 1 antibody;FLJ33898 antibody;FLJ34109 antibody;FLJ43328 antibody;KDM1B antibody;KDM1B_HUMAN antibody;LSD2 antibody;lysine (K)-specific demethylase 1B antibody;Lysine-specific demethylase 2 antibody;Lysine-specific histone demethylase 1B antibody;Lysine-specific histone demethylase 2 antibody

SUBCELLULAR LOCATION

Chromosome. Nucleus.

FUNCTION

Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of GLYR1 to achieve such activity, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes.