Biotin Conjugated Human PDGF-BB Recombinant Rabbit Monoclonal Antibody [PSH05-99] - Detector

Function

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA. A form of basal ganglia calcification, an autosomal dominant condition characterized by symmetric calcification in the basal ganglia and other brain regions. Affected individuals can either be asymptomatic or show a wide spectrum of neuropsychiatric symptoms, including parkinsonism, dystonia, tremor, ataxia, dementia, psychosis, seizures, and chronic headache. Serum levels of calcium, phosphate, alkaline phosphatase and parathyroid hormone are normal. The neuropathological hallmark of the disease is vascular and pericapillary calcification, mainly of calcium phosphate, in the affected brain areas.

Background References

1. Vanlandewijck M., Lebouvier T., Andaloussi Maee M., Nahar K., Hornemann S., Kenkel D., Cunha S.I., Lennartsson J., Boss A., Betsholtz C. Functional characterization of germline mutations in PDGFB and PDGFRB in primary familial brain calcification. PLoS ONE 10:E0143407-E0143407 (2015)

2. Keller A., Westenberger A., Sobrido M.J., Garcia-Murias M., Domingo A., Sears R.L., Lemos R.R., Ordonez-Ugalde A., Nicolas G., Oliveira J.R. Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice. Nat. Genet. 45:1077-1082 (2013)

Subcellular Location

Secreted

UNIPROT

SwissProt: P01127 Human

Synonyms