Biotin Conjugated Rat IL-4 Recombinant Rabbit Monoclonal Antibody [PSH04-22] (HA722614B)

UNIPROT #

P20096

PROTEIN NAME

Rat IL-4

SYNONYMS

B cell growth factor 1 antibody;B cell IgG differentiation factor antibody;B Cell Stimulatory Factor 1 antibody;B-cell stimulatory factor 1 antibody;BCGF 1 antibody;BCGF1 antibody;Binetrakin antibody;BSF-1 antibody;BSF1 antibody;IGG1 induction factor antibody;IL 4 antibody;IL-4 antibody;IL4 antibody;IL4_HUMAN antibody;Il4e12 antibody;Interleukin 4 antibody;Interleukin 4 variant 2 antibody;Interleukin 4, isoform 1 antibody;Interleukin-4 antibody;Lymphocyte stimulatory factor 1 antibody;MGC79402 antibody;Pitrakinra antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon activation by IL-4, Th2 cells subsequently produce additional IL-4 in a positive feedback loop. IL-4 is produced primarily by mast cells, Th2 cells, eosinophils and basophils. It is closely related and has functions similar to IL-13. Interleukin 4 has many biological roles, including the stimulation of activated B cell and T cell proliferation, and the differentiation of B cells into plasma cells. It is a key regulator in humoral and adaptive immunity. IL-4 induces B cell class switching to IgE, and up-regulates MHC class II production. IL-4 decreases the production of Th1 cells, macrophages, IFNγ, and dendritic cells IL-12. Overproduction of IL-4 is associated with allergies.