Biotin Conjugated Human HGF Recombinant Rabbit Monoclonal Antibody [PSH02-07] (HA722640B)

UNIPROT #

P14210

PROTEIN NAME

Human HGF

SYNONYMS

DFNB39 antibody;F TCF antibody;Fibroblast derived tumor cytotoxic factor antibody;Hepatocyte growth factor (hepapoietin A; scatter factor) antibody;Hepatocyte growth factor antibody;Hepatocyte growth factor beta chain antibody;Hepatocyte growth factor precursor antibody;Hepatopoietin A antibody;Hepatopoietin-A antibody;Hgf antibody;HGF_HUMAN antibody;HGFB antibody;HPTA antibody;Lung fibroblast derived mitogen antibody;OTTHUMP00000161349 antibody;OTTHUMP00000206710 antibody;OTTHUMP00000206711 antibody;OTTHUMP00000206712 antibody;OTTHUMP00000206713 antibody;OTTHUMP00000206730 antibody;Scatter factor antibody;SF antibody

SUBCELLULAR LOCATION

extracellular region, extracellular space

FUNCTION

HGF, also known as scatter factor and hepatopoietin A, is a pleiotropic protein in the plasminogen subfamily of S1 peptidases. It is a multidomain molecule that includes an N-terminal PAN/APPLE-like domain, four Kringle domains, and a serine proteinase-like domain that has no detectable protease activity Human HGF is secreted as an inactive 728 amino acid (aa) single chain propeptide. It is cleaved after the fourth Kringle domain by a serine protease to form bioactive disulfide-linked HGF with a 60 kDa alpha and 30 kDa beta chain. Alternate splicing generates human HGF isoforms that lack the proteinase-like domain and different numbers of the Kringle domains. Human HGF shares 91%-94% aa sequence identity with bovine, canine, feline, mouse, and rat HGF. HGF binds heparan-sulfate proteoglycans and the widely expressed receptor tyrosine kinase, HGF R/c-MET. HGF-dependent c-MET activation is implicated in the development of many human cancers. HGF regulates epithelial morp.