Interferon gamma Recombinant Rabbit Monoclonal Antibody [JM10-10] - BSA and Azide free

Function

Interferon gamma (IFN-γ) is a dimerized soluble cytokine that is the only member of the type II class of interferons. In humans, the IFN-γ protein is encoded by the IFNG gene. IFN-γ, or type II interferon, is a cytokine that is critical for innate and adaptive immunity against viral, some bacterial and protozoan infections. IFN-γ is an important activator of macrophages and inducer of major histocompatibility complex class II molecule expression. Aberrant IFN-γ expression is associated with a number of autoinflammatory and autoimmune diseases. The importance of IFN-γ in the immune system stems in part from its ability to inhibit viral replication directly, and most importantly from its immunostimulatory and immunomodulatory effects. IFN-γ is produced predominantly by natural killer cells (NK) and natural killer T cells (NKT) as part of the innate immune response, and by CD4 Th1 and CD8 cytotoxic T lymphocyte (CTL) effector T cells once antigen-specific immunity develops as part of the adaptive immune response. IFN-γ is also produced by non-cytotoxic innate lymphoid cells (ILC), a family of immune cells first discovered in the early 2010s.

Background References

1. Kaewkangsadan V et al. Crucial Contributions by T Lymphocytes (Effector, Regulatory, and Checkpoint Inhibitor) and Cytokines (TH1, TH2, and TH17) to a Pathological Complete Response Induced by Neoadjuvant Chemotherapy in Women with Breast Cancer. J Immunol Res 2016:4757405 (2016).

2. Srivastava SP et al. Effect of Antifibrotic MicroRNAs Crosstalk on the Action of N-acetyl-seryl-aspartyl-lysyl-proline in Diabetes-related Kidney Fibrosis. Sci Rep 6:29884 (2016).

Sequence Similarity

Belongs to the type II (or gamma) interferon family.

Tissue Specificity

Released primarily from activated T lymphocytes.

Post-translational Modification

Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.

Subcellular Location

Secreted.

UNIPROT

SwissProt: P01579 Human

Synonyms

IFG antibody

IFI antibody

IFN gamma antibody

IFN, immune antibody

IFN-gamma antibody

IFNG antibody

IFNG_HUMAN antibody

Immune interferon antibody

Interferon gamma antibody