HRP Conjugated Human Antithrombin III / ATIII Recombinant Rabbit Monoclonal Antibody [PSH14-26] - Detector

Function

The protein encoded by this gene, antithrombin III, is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. Numerous mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency which constitutes a strong risk factor for thrombosis. A reduction in the serum level of this protein is associated with severe cases of Coronavirus Disease 19 (COVID-19).

Background References

1. Corral J., Huntington J.A., Gonzalez-Conejero R., Mushunje A., Navarro M., Marco P., Vicente V., Carrell R.W. Mutations in the shutter region of antithrombin result in formation of disulfide-linked dimers and severe venous thrombosis. J. Thromb. Haemost. 2:931-939 (2004)

2. Szabo R., Netzel-Arnett S., Hobson J.P., Antalis T.M., Bugge T.H. Matriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivity. Biochem. J. 390:231-242 (2005)

Subcellular Location

Secreted.

UNIPROT

SwissProt: P01008 Human

Synonyms