CD34 Recombinant Rabbit Monoclonal Antibody

Function

CD34 is a heavily glycosylated, transmembrane glycoprotein that is expressed on the surface of lymphohematopoietic stem and progenitor cells, small-vessel endothelial cells, embryonic fibroblasts and some cells in fetal and adult nervous tissue. CD34 antigen expression is highest in the most primitive stem cells and is gradually lost as lineage committed progenitors differentiate. The CD34 antigen is also present on capillary endothelial cells and on bone marrow stromal cells. The CD34 cytoplasmic domain has an intracellular domain that contains consensus sites for activated protein kinase C (PKC) phosphorylation as well as serine, threonine and tyrosine phosphorylation consensus sites.

Background References

1. Lin, SZ. et al. 2015. Emodin inhibits angiogenesis in pancreatic cancer by regulating the transforming growth factor-β/drosophila mothers against decapentaplegic pathway and angiogenesis-associated microRNAs. Molecular medicine reports. 12: 5865-71.

2. Corradi, LS. et al. 2013. Structural and ultrastructural evidence for telocytes in prostate stroma. J. Cell. Mol. Med. 17: 398-406.

Sequence Similarity

Belongs to the CD34 family.

Tissue Specificity

Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues.

Post-translational Modification

Highly glycosylated.; Phosphorylated on serine residues by PKC.

Subcellular Location

Membrane.

UNIPROT

SwissProt: P28906 Human

Synonyms

CD34 antibody

CD34 antigen antibody

CD34 molecule antibody

CD34_HUMAN antibody

Cluster designation 34 antibody

Hematopoietic progenitor cell antigen CD34 antibody

HPCA1 antibody

Mucosialin antibody

OTTHUMP00000034733 antibody

OTTHUMP00000034734 antibody