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pan Cytokeratin Recombinant Mouse Monoclonal Antibody (IRS010)

Price: Regular price $209.00

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Catalog# IRS010

Mouse Monoclonal to pan Cytokeratin

Tested for

  • mIHC

Reacts with

  • Human

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free

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Specifications

Product Type

Recombinant Mouse monoclonal primary

Product Name

pan Cytokeratin Recombinant Mouse Monoclonal Antibody (IRS010)

Immunogen

Full length native protein corresponding to human pan cytokeratin.

Host

Mouse

Positive Control

Human cholangiocarcinoma tissue, human lung cancer with brain metastasis tissue, human colorectal cancer tissue, human gastric cancer tissue, human small cell lung cancer tissue, human pancreatic cancer tissue, human tonsil tissue, human ovarian cancer tissue, human lung squamous cell carcinoma tissue, human liver tissue, human intrahepatic bile duct carcinoma tissue, human gastric cancer tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

APPLICATION DILUTION

  • mIHC

  • 1:100. This antibody has been validated for multiplex staining with LUMINIRIS mTSA, supporting both multiplex and super-multiplex staining.

PROPERTIES

Form

Liquid

Storage Condition

Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.

Storage Buffer

PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Purification

Protein A affinity purified.

Isotype

IgG1

TARGET

UNIPROT #

Q01546

PROTEIN NAME

pan Cytokeratin

SYNONYMS

pan Cytokeratin antibody;pan-Cytokeratin antibody;pan ck antibody;pan Keratin antibody;pan-ck antibody;panck antibody

SUBCELLULAR LOCATION

Cytoplasmic

FUNCTION

Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins have been found to be useful markers of tissue differentiation which is directly applicable to the characterization of malignant tumors. For example, cytokeratins 10 and 13 are expressed highly in a subset of squamous cell carcinomas while cytokeratin 18 is expressed in a majority of adenocarcinomas and basal cell carcinomas. Since each epithelium contains at least one acidic and one basic keratin, this antibody is used to observe the distribution of keratin-containing cells in normal epithelia and to identify neoplasms derived from such epithelium. Recognizes humancytokeratins 10, 14, 15, 16 and 19, and cytokeratins 1, 2, 3, 4, 5, 6, 7 and 8.

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