CD4 Recombinant Rabbit Monoclonal Antibody (IRS005)

UNIPROT #

P01730

PROTEIN NAME

CD4

SYNONYMS

CD 4 antibody;CD4 (L3T4) antibody;CD4 antibody;CD4 antigen (p55) antibody;CD4 antigen antibody;CD4 molecule antibody;CD4 receptor antibody;CD4+ Lymphocyte deficiency, included antibody;CD4_HUMAN antibody;CD4mut antibody;L3T4 antibody;Leu3 antibody;Ly-4 antibody;Lymphocyte antigen CD4 antibody;MGC165891 antibody;OTTHUMP00000238897 antibody;p55 antibody;T cell antigen T4 antibody;T cell antigen T4/LEU3 antibody;T cell differentiation antigen L3T4 antibody;T cell OKT4 deficiency, included antibody;T cell surface antigen T4/Leu 3 antibody;T cell surface antigen T4/Leu3 antibody;T cell surface glycoprotein CD4 antibody;T-cell surface antigen T4/Leu-3 antibody;T-cell surface glycoprotein CD4 antibody;W3/25 antibody;W3/25 antigen antibody

TISSUE SPECIFICITY

Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells such as macrophages, dendritic cells or NK cells.

POST-TRANSLATIONAL MODIFICATION

Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.; Phosphorylated by PKC; phosphorylation at Ser-433 plays an important role for CD4 internalization.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

The T cell receptor (TCR) is a heterodimer composed of either α and β or γ and δ chains. CD3 chains and the CD4 or CD8 co-receptors are also required for efficient signal transduction through the TCR. The TCR is expressed on T helper and T cytotoxic cells that can be distinguished by their expression of CD4 and CD8; T helper cells express CD4 proteins and T cytotoxic cells display CD8. CD4 is also expressed on cortical cells, mature medullary thymocytes, microglial cells and dendritic cells. CD4 (also designated T4 and Leu 3), is a membrane glycoprotein that contains four extracellular immunoglobin-like domains. The TCR in association with CD4 can bind class II MHC molecules presented by the antigen-presenting cells. The CD4 protein functions by increasing the avidity of the interaction between the TCR and an antigen-class II MHC complex. An additional role of CD4 is to function as a receptor for HIV.