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CD38 Recombinant Rabbit Monoclonal Antibody

Usd: 209

Specification

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Catalog# IRS006

CD38 Recombinant Rabbit Monoclonal Antibody

Application

  • mIHC

Reactivity

  • Human

Conjugation

  • unconjugated

Overview

Product Name

CD38 Recombinant Rabbit Monoclonal Antibody

Antibody Type

Recombinant Rabbit monoclonal Antibody

Immunogen

Synthetic peptide within human CD38 aa 250-300.

Species Reactivity

Human

Validated Applications

mIHC

Positive Control

Human cholangiocarcinoma tissue, human tonsil tissue, human gastric cancer tissue.

Conjugation

unconjugated

Product Features

Form

Liquid

Concentration

(The concentration of this product may be batch-dependent)

Storage Instructions

Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.

Storage Buffer

PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Isotype

IgG

Purification Method

Protein A affinity purified.

Application Dilution

  • mIHC

  • 1:100. This antibody has been validated for multiplex staining with LUMINIRIS mTSA, supporting both multiplex and super-multiplex staining.

Target

Function

CD38 is a type II integral membrane glycoprotein which is present on early B and T cell lineages and activated B and T cells but is absent from most mature resting peripheral lymphocytes. CD38 is also found on thymocytes, pre-B cells, germinal center B cells, mitogen-activated T cells, monocytes and Ig-secreting plasma cells. CD38 acts as a NAD glycohydrolase in T lymphocytes. On hematopoietic cells CD38 induces activation, proliferation, and differentiation of mature T and B cells and mediates apoptosis of myeloid and lymphoid progenitor cells. In addition to acting as a signaling receptor, CD38 is also an enzyme capable of producing several calcium-mobilizing metabolites, including cyclic adenosine diphosphate ribose (cADPR). CD38 also plays a role in maintaining survival of an invariant NK T (iNKT) cell subset that preferentially contributes to the maintenance of immunological tolerance.

Background References

1. Yang Q et al. NADase CD38 is a key determinant of ovarian aging. Nat Aging. 2024 Jan

2. Yu S et al. CD38-Targeting Peptide Vaccine Ameliorates Aging-Associated Phenotypes in Mice. Aging Cell. 2025 Sep

Subcellular Location

Membrane.

UNIPROT

SwissProt: P28907 Human

Synonyms

Acute lymphoblastic leukemia cells antigen CD38 antibody

ADP ribosyl cyclase 1 antibody

ADP ribosyl cyclase antibody

ADP ribosyl cyclase/cyclic ADP-ribose hydrolase antibody

ADP-ribosyl cyclase 1 antibody

ADPRC 1 antibody

ADPRC1 antibody

cADPr hydrolase 1 antibody

CD 38 antibody

CD38 antibody

Expand

Images

  • mIHC analysis of human cholangiocarcinoma tissue (Formalin/PFA-fixed paraffin-embedded sections) with CD11c (<a href="/products/IRS001" style="font-weight: bold;text-decoration: underline;">IRS001</a>), CD68 (<a href="/products/IRS004" style="font-weight: bold;text-decoration: underline;">IRS004</a>), CD20 (<a href="/products/IRS003" style="font-weight: bold;text-decoration: underline;">IRS003</a>), CD38 (<a href="/products/IRS006" style="font-weight: bold;text-decoration: underline;">IRS006</a>), CD8 and panCK (<a href="/products/IRS010" style="font-weight: bold;text-decoration: underline;">IRS010</a>) antibody at 1/100 dilution. The immunostaining was performed with the IRISKitCmTSA Kit (<a href="/products/900802" style="font-weight: bold;text-decoration: underline;">900802</a>). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.

    mIHC analysis of human cholangiocarcinoma tissue (Formalin/PFA-fixed paraffin-embedded sections) with CD11c (IRS001), CD68 (IRS004), CD20 (IRS003), CD38 (IRS006), CD8 and panCK (IRS010) antibody at 1/100 dilution. The immunostaining was performed with the IRISKitCmTSA Kit (900802). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.

  • mIHC analysis of human tonsil tissue (Formalin/PFA-fixed paraffin-embedded sections) with CD8, CD4 (<a href="/products/IRS005" style="font-weight: bold;text-decoration: underline;">IRS005</a>), FOXP3, CD68 (<a href="/products/IRS004" style="font-weight: bold;text-decoration: underline;">IRS004</a>), CD38 (<a href="/products/IRS006" style="font-weight: bold;text-decoration: underline;">IRS006</a>), CD11c (<a href="/products/IRS001" style="font-weight: bold;text-decoration: underline;">IRS001</a>), PD-L1, CD163 (<a href="/products/IRS002" style="font-weight: bold;text-decoration: underline;">IRS002</a>) and CD20 (<a href="/products/IRS003" style="font-weight: bold;text-decoration: underline;">IRS003</a>) antibody at 1/100 dilution. The immunostaining was performed with the IRISKitCmTSA Kit (<a href="/products/900802" style="font-weight: bold;text-decoration: underline;">900802</a>). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.

    mIHC analysis of human tonsil tissue (Formalin/PFA-fixed paraffin-embedded sections) with CD8, CD4 (IRS005), FOXP3, CD68 (IRS004), CD38 (IRS006), CD11c (IRS001), PD-L1, CD163 (IRS002) and CD20 (IRS003) antibody at 1/100 dilution. The immunostaining was performed with the IRISKitCmTSA Kit (900802). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.

  • mIHC analysis of human tonsil tissue (Formalin/PFA-fixed paraffin-embedded sections) with CD38 (<a href="/products/IRS006" style="font-weight: bold;text-decoration: underline;">IRS006</a>), CD57 (<a href="/products/IRS027" style="font-weight: bold;text-decoration: underline;">IRS027</a>), CD11c (<a href="/products/IRS001" style="font-weight: bold;text-decoration: underline;">IRS001</a>), Tryptase (<a href="/products/IRS041" style="font-weight: bold;text-decoration: underline;">IRS041</a>) and CD45 (<a href="/products/IRS025" style="font-weight: bold;text-decoration: underline;">IRS025</a>) antibody at 1/100 dilution. The immunostaining was performed with the IRISKitCmTSA Kit (<a href="/products/900802" style="font-weight: bold;text-decoration: underline;">900802</a>). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.

    mIHC analysis of human tonsil tissue (Formalin/PFA-fixed paraffin-embedded sections) with CD38 (IRS006), CD57 (IRS027), CD11c (IRS001), Tryptase (IRS041) and CD45 (IRS025) antibody at 1/100 dilution. The immunostaining was performed with the IRISKitCmTSA Kit (900802). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.

  • mIHC analysis of human gastric cancer tissue (Formalin/PFA-fixed paraffin-embedded sections) with CD21 (<a href="/products/IRS019" style="font-weight: bold;text-decoration: underline;">IRS019</a>), PD-1, CD14 (<a href="/products/IRS015" style="font-weight: bold;text-decoration: underline;">IRS015</a>), CD38 (<a href="/products/IRS006" style="font-weight: bold;text-decoration: underline;">IRS006</a>), aSMA (<a href="/products/IRS012" style="font-weight: bold;text-decoration: underline;">IRS012</a>) and CK7 (<a href="/products/IRS029" style="font-weight: bold;text-decoration: underline;">IRS029</a>) antibody at 1/100 dilution. The immunostaining was performed with the IRISKitCmTSA Kit (<a href="/products/900802" style="font-weight: bold;text-decoration: underline;">900802</a>). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.

    mIHC analysis of human gastric cancer tissue (Formalin/PFA-fixed paraffin-embedded sections) with CD21 (IRS019), PD-1, CD14 (IRS015), CD38 (IRS006), aSMA (IRS012) and CK7 (IRS029) antibody at 1/100 dilution. The immunostaining was performed with the IRISKitCmTSA Kit (900802). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.

  • mIHC analysis of human tonsil tissue (Formalin/PFA-fixed paraffin-embedded sections) with Rabbit anti-CD38 antibody (<a href="/products/IRS006" style="font-weight: bold;text-decoration: underline;">IRS006</a>) at 1/100 dilution. The immunostaining was performed with the IRISKitCmTSA Kit (<a href="/products/900808" style="font-weight: bold;text-decoration: underline;">900808</a>). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.

    mIHC analysis of human tonsil tissue (Formalin/PFA-fixed paraffin-embedded sections) with Rabbit anti-CD38 antibody (IRS006) at 1/100 dilution. The immunostaining was performed with the IRISKitCmTSA Kit (900808). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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