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CD11b Recombinant Rabbit Monoclonal Antibody (IRS014)

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Catalog# IRS014

Rabbit Monoclonal to CD11b

Tested for

  • mIHC

Reacts with

  • Human

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

CD11b Recombinant Rabbit Monoclonal Antibody (IRS014)

Immunogen

Synthetic peptide within human cd11b 1103-1152 / 1152.

Host

Rabbit

Positive Control

Human gastric cancer tissue, human liver tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

APPLICATION DILUTION

  • mIHC

  • 1:100

PROPERTIES

Form

Liquid

Storage Condition

Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.

Storage Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 127 kDa

Isotype

IgG

TARGET

UNIPROT #

P11215

PROTEIN NAME

CD11b

SYNONYMS

antigen CD11b (p170) antibody;Antigen CD11b p170 antibody;CD11 antigen like family member B antibody;CD11 antigen-like family member B antibody;CD11b antibody;CD11b/CD18 antibody;CD49d antibody;Cell surface glycoprotein MAC-1 subunit alpha antibody;Complement component 3 receptor 3 subunit antibody;Complement Component Receptor 3 Alpha antibody;Complement receptor type 3, alpha subunit antibody;CR 3 alpha chain (CR3A) antibody;CR 3 alpha chain antibody;CR-3 alpha chain antibody;CR3 antibody;CR3A antibody;F730045J24Rik antibody;Integrin Alpha M antibody;Integrin alpha M chain antibody;Integrin alpha-M antibody;Integrin beta 2 alpha subunit antibody;Integrin subunit alpha M antibody;integrin, alpha M (complement component 3 receptor 3 subunit) antibody;ITAM_HUMAN antibody;ITGAM antibody;Leukocyte adhesion receptor MO1 antibody;Ly-40 antibody;MAC 1 antibody;Mac-1a antibody;MAC1 antibody;Mac1, alpha subunit antibody;MAC1A antibody;Macrophage antigen alpha polypeptide antibody;MGC117044 antibody;Mo1, alpha subunit antibody;MO1A antibody;Neutrophil adherence receptor alpha M subunit antibody;Neutrophil adherence receptor antibody;SLEB6 antibody

SEQUENCE SIMILARITIES

Belongs to the integrin alpha chain family.

TISSUE SPECIFICITY

Predominantly expressed in monocytes and granulocytes. Expressed in neutrophils (at protein level).

SUBCELLULAR LOCATION

Cell membrane, Membrane raft.

FUNCTION

Integrin αM, also designated complement component receptor-3 α, CD11b (p170), macrophage antigen a polypeptide, cell surface glycoprotein Mac-1 a subunit, MAC1A, MO1A and ITGAM) is a cell adhesion molecule that acts as a receptor for cell surface ligands such as intracellular adhesion molecules (ICAMs) or soluble ligands. Integrins are heterodimeric proteins that contain an a chain and b chain. Integrin αM combines with the Integrin β2 to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3). Integrin αM/β2 is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles.

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