E-Cadherin Recombinant Mouse Monoclonal Antibody

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.

Background References

1. Thomas E Meigs et al. Galpha12 and Galpha13 negatively regulate the adhesive functions of cadherin. J Biol Chem 277(27):24594-600 (2002)

2. Georgia Agiostratidou et al. The cytoplasmic sequence of E-cadherin promotes non-amyloidogenic degradation of A beta precursors. 96(4):1182-8 (2006)

Subcellular Location

Cell membrane, Endosome, Golgi apparatus.

UNIPROT

SwissProt: P12830 Human

Synonyms

Cadherin-1

CAM 120/80

Epithelial cadherin (E-cadherin)

Uvomorulin