Cytokeratin 20 Recombinant Rabbit Monoclonal Antibody (IRS135RB)

UNIPROT #

P35900

PROTEIN NAME

Cytokeratin 20

SYNONYMS

CD20 antibody;CK 20 antibody;CK-20 antibody;CK20 antibody;Cytokeratin-20 antibody;Cytokeratin20 antibody;K1C20_HUMAN antibody;K20 antibody;KA20 antibody;Keratin 20 antibody;keratin 20, type I antibody;keratin 21, rat, homolog of antibody;Keratin antibody;Keratin type I cytoskeletal 20 antibody;Keratin-20 antibody;Keratin20 antibody;KRT 20 antibody;KRT 21 antibody;KRT20 antibody;KRT21 antibody;MGC35423 antibody;OTTHUMP00000164518 antibody;Protein IT antibody;type I cytoskeletal 20 antibody

SUBCELLULAR LOCATION

Cytoplasm

FUNCTION

Keratin 20, often abbreviated CK20, is a protein that in humans is encoded by the KRT20 gene. Keratin 20 is a type I cytokeratin. It is a major cellular protein of mature enterocytes and goblet cells and is specifically found in the gastric and intestinal mucosa. In immunohistochemistry, antibodies to CK20 can be used to identify a range of adenocarcinoma arising from epithelia that normally contain the CK20 protein. For example, the protein is commonly found in colorectal cancer, transitional cell carcinomas and in Merkel cell carcinoma, but is absent in lung cancer, prostate cancer, and non-mucinous ovarian cancer. It is often used in combination with antibodies to CK7 to distinguish different types of glandular tumour.