Von Willebrand Factor Recombinant Rabbit Monoclonal Antibody
Catalog# IRS215RB
Von Willebrand Factor Recombinant Rabbit Monoclonal Antibody
-
mIHC
-
Human
-
unconjugated
Overview
Product Name
Von Willebrand Factor Recombinant Rabbit Monoclonal Antibody
Antibody Type
Recombinant Rabbit monoclonal Antibody
Immunogen
Recombinant protein within human Von Willebrand Factor aa 734-1,283.
Species Reactivity
Human
Validated Applications
mIHC
Molecular Weight
Predicted band size: 309 kDa
Positive Control
Human liver tissue.
Conjugation
unconjugated
Product Features
Form
Liquid
Concentration
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 0.1% BSA, 40% Glycerol, 0.2% Proclean 950.
Isotype
IgG
Purification Method
Protein A affinity purified.
Application Dilution
-
mIHC
-
1:100
Target
Function
Von Willebrand factor (VWF) is a blood glycoprotein that promotes hemostasis, specifically, platelet adhesion. It is deficient and/or defective in von Willebrand disease and is involved in many other diseases, including thrombotic thrombocytopenic purpura, Heyde's syndrome, and possibly hemolytic–uremic syndrome. Increased plasma levels in many cardiovascular, neoplastic, metabolic (e.g. diabetes), and connective tissue diseases are presumed to arise from adverse changes to the endothelium, and may predict an increased risk of thrombosis.
Background References
1. Manz XD et al. Regulation of VWF (Von Willebrand Factor) in Inflammatory Thrombosis. Arterioscler Thromb Vasc Biol. 2022 Nov
2. Groeneveld D et al. Von Willebrand factor delays liver repair after acetaminophen-induced acute liver injury in mice. J Hepatol. 2020 Jan
Subcellular Location
Secreted, extracellular space, extracellular matrix.
UNIPROT
Synonyms
Coagulation factor VIII antibody
Coagulation factor VIII VWF antibody
F8VWF antibody
Factor VIII related antigen antibody
von Willebrand antigen 2 antibody
von Willebrand antigen II antibody
Von Willebrand disease antibody
Von Willebrand factor precursor antibody
VWD antibody
vWF antibody
ExpandImages
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mIHC analysis of human liver tissue (Formalin/PFA-fixed paraffin-embedded sections) with Rabbit anti-Von Willebrand Factor antibody (IRS215RB) at 1/100 dilution. The immunostaining was performed with the IRISKitCmTSA Kit (900808). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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