Pan-Cadherin Recombinant Antibody - Rat IgG1 (Chimeric)

Function

Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH₂ terminal repeats. The most distal of these cadherins is thought to be responsible for binding specificity, transmembrane domains and carboxy terminal intracellular domains. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as -catenin, to regulate cadherin function. Members of this family of adhesion proteins include rat cadherin K (and its human homolog, cadherin, R-cadherin, B-cadherin, E/P cadherin and cadherin-5.

Background References

1. Li J et al. Anti-KCNQ1 K+ channel autoantibodies increase IKs current and are associated with QT interval shortening in dilated cardiomyopathy. Cardiovasc Res 98:496-503 (2013).

2. Izumi H & Kaneko Y Evidence of asymmetric cell division and centrosome inheritance in human neuroblastoma cells. Proc Natl Acad Sci U S A 109:18048-53 (2012).

Subcellular Location

Cell membrane, Cell junction, Endosome, Golgi apparatus.

UNIPROT

SwissProt: P12830 Human

SwissProt: P19022 Human

SwissProt: P22223 Human

SwissProt: P33151 Human

SwissProt: P55283 Human

Synonyms