Monoamine Oxidase A / MAO-A Rabbit Polyclonal Antibody

Function

Monoamine oxidase A is an enzyme that degrades amine neurotransmitters, such as dopamine, norepinephrine, and serotonin. The protein localizes to the outer mitochondrial membrane. Its encoding gene is adjacent to a related gene (MAOB) on the opposite strand of the X chromosome. MAO-A levels in the brain as measured using positron emission tomography are elevated by an average of 34% in patients with major depressive disorder. Genetic association studies examining the relationship between high-activity MAOA variants and depression have produced mixed results, with some studies linking the high-activity variants to major depression in females, depressed suicide in males, major depression and sleep disturbance in males and major depressive disorder in both males and females.

Background References

1. "Three-dimensional structure of human monoamine oxidase A (MAO A): relation to the structures of rat MAO A and human MAO B." De Colibus L., Li M., Binda C., Lustig A., Edmondson D.E., Mattevi A. Proc. Natl. Acad. Sci. U.S.A. 102:12684-12689(2005)

2. "Structure of human monoamine oxidase A at 2.2-A resolution: the control of opening the entry for substrates/inhibitors." Son S.-Y., Ma J., Kondou Y., Yoshimura M., Yamashita E., Tsukihara T. Proc. Natl. Acad. Sci. U.S.A. 105:5739-5744(2008)

3. "Monoamine oxidase A expression is suppressed in human cholangiocarcinoma via coordinated epigenetic and IL-6-driven events". Huang L, Frampton G, Rao A, Zhang KS, Chen W, Lai JM, Yin XY, Walker K, Culbreath B, Leyva-Illades D, Quinn M, McMillin M, Bradley M, Liang LJ, DeMorrow S (October 2012). Lab Invest. 92 (10): 1451–60.

Sequence Similarity

Belongs to the flavin monoamine oxidase family.

Tissue Specificity

Heart, liver, duodenum, blood vessels and kidney.

Subcellular Location

Mitochondrion outer membrane.

UNIPROT

SwissProt: P21397 Human

Synonyms

Amine oxidase [flavin containing] A antibody

Amine oxidase [flavin-containing] A antibody

AOFA antibody

AOFA_HUMAN antibody

EC 1.4.3.4 antibody

MAO A antibody

MAO-A antibody

maoA antibody

Monoamine oxidase A antibody

Monoamine oxidase type A antibody