Monoamine oxidase A Rabbit Polyclonal Antibody (R1408-8)

UNIPROT #

P21397

PROTEIN NAME

Monoamine oxidase A

SYNONYMS

Amine oxidase [flavin containing] A antibody;Amine oxidase [flavin-containing] A antibody;AOFA antibody;AOFA_HUMAN antibody;EC 1.4.3.4 antibody;MAO A antibody;MAO-A antibody;maoA antibody;Monoamine oxidase A antibody;Monoamine oxidase type A antibody

SEQUENCE SIMILARITIES

Belongs to the flavin monoamine oxidase family.

TISSUE SPECIFICITY

Heart, liver, duodenum, blood vessels and kidney.

SUBCELLULAR LOCATION

Mitochondrion outer membrane.

FUNCTION

Monoamine oxidase A is an enzyme that degrades amine neurotransmitters, such as dopamine, norepinephrine, and serotonin. The protein localizes to the outer mitochondrial membrane. Its encoding gene is adjacent to a related gene (MAOB) on the opposite strand of the X chromosome. MAO-A levels in the brain as measured using positron emission tomography are elevated by an average of 34% in patients with major depressive disorder. Genetic association studies examining the relationship between high-activity MAOA variants and depression have produced mixed results, with some studies linking the high-activity variants to major depression in females, depressed suicide in males, major depression and sleep disturbance in males and major depressive disorder in both males and females.