Mouse CD8 alpha Recombinant Rat Monoclonal Antibody [PSH16-78]

Function

CD8 is a pivotal integral membrane glycoprotein that is crucial for immune responses. In T-cells, CD8 primarily acts as a coreceptor for the MHC class I molecule:peptide complex. It simultaneously interacts with the T-cell receptor (TCR) and MHC class I proteins presented by antigen-presenting cells (APCs). This interaction recruits the Src kinase LCK to the TCR-CD3 complex, initiating intracellular signaling pathways. These pathways lead to lymphokine production, motility, adhesion, and activation of cytotoxic T-lymphocytes (CTLs), enabling CTLs to recognize and eliminate infected and tumor cells. In NK-cells, CD8A homodimers on the cell surface provide a survival mechanism. They facilitate conjugation and lysis of multiple target cells and promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells. Overall, CD8 is indispensable in both T-cell mediated cellular immunity and NK-cell mediated natural immunity, offering strong protection against pathogens and internal anomalies.

Background References

1. Alromaih et al. CD8A gene polymorphisms predict severity factors in chronic rhinosinusitis. Int Forum Allergy Rhinol. 2013 Aug

2. Kristensen LK et al. CD4+ and CD8a+ PET imaging predicts response to novel PD-1 checkpoint inhibitor: studies of Sym021 in syngeneic mouse cancer models. Theranostics. 2019 Oct

Subcellular Location

Cell membrane.

UNIPROT

SwissProt: P01731 Mouse

Synonyms