AK6 Rabbit Polyclonal Antibody

Function

Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred substrates, but CMP and dCMP are also good substrates. IMP is phosphorylated to a much lesser extent. All nucleoside triphosphates ATP, GTP, UTP, CTP, dATP, dCTP, dGTP, and TTP are accepted as phosphate donors. CTP is the best phosphate donor, followed by UTP, ATP, GTP and dCTP. AK6 may have a role in nuclear energy homeostasis. It has also ATPase activity and may be involved in regulation of Cajal body (CB) formation.

Background References

1. Characterization of hCINAP, a novel coilin-interacting protein encoded by a transcript from the transcription factor TAFIID32 locus. Santama N., Ogg S.C., Malekkou A., Zographos S.E., Weis K., Lamond A.I. J. Biol. Chem. 280:36429-36441(2005)

2. hCINAP is an atypical mammalian nuclear adenylate kinase with an ATPase motif: structural and functional studies. Drakou C.E., Malekkou A., Hayes J.M., Lederer C.W., Leonidas D.D., Oikonomakos N.G., Lamond A.I., Santama N., Zographos S.E. Proteins 80:206-220(2012)

Sequence Similarity

Belongs to the adenylate kinase family. AK6 subfamily.

Tissue Specificity

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, chorionic villi and the central nervous system.

Subcellular Location

Nucleus

UNIPROT

SwissProt: Q9Y3D8 Human

Synonyms