Cathepsin D Mouse Monoclonal Antibody [13F2] (EM1901-15)

UNIPROT #

P07339

PROTEIN NAME

Cathepsin D

SYNONYMS

CatD antibody;CATD_HUMAN antibody;Cathepsin D antibody;Cathepsin D heavy chain antibody;CD antibody;Ceroid lipofuscinosis neuronal 10 antibody;CLN10 antibody;CPSD antibody;ctsd antibody;Epididymis secretory sperm binding protein Li 130P antibody;HEL S 130P antibody;Lysosomal aspartyl peptidase antibody;Lysosomal aspartyl protease antibody;MGC2311 antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase A1 family.

TISSUE SPECIFICITY

Expressed in the aorta extracellular space (at protein level). Expressed in liver (at protein level).

POST-TRANSLATIONAL MODIFICATION

N- and O-glycosylated.; Undergoes proteolytic cleavage and activation by ADAM30.; As well as the major heavy chain which starts at Leu-169, 2 minor forms starting at Gly-170 and Gly-171 have been identified. An additional form starting at Ala-168 has also been identified.

SUBCELLULAR LOCATION

Lysosome, extracellular space, melanosome.

FUNCTION

Cathepsin D is a protein that in humans is encoded by the CTSD gene. The main function of cathepsin D is to degrade proteins and activate precursors of bioactive proteins in pre-lysosomal compartments. This proteinase, which is a member of the peptidase A1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of the CTSD gene is initiated from several sites, including one that is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. Homozygous deletion of the CTSD gene leads to early lethality in the postnatal phase. Over-expression of cathepsin D stimulates tumorigenicity and metastasis as well as initiation of tumor apoptosis. This protease has been regarded an independent marker of poor prognosis in breast cancer being correlated with the incidence of clinical metastasis. Knock-out of CTSD gene would cause intestinal necrosis and hemorrhage and increase apoptosis in thymus, indicating that cathepsin D is required in certain epithelial cells for tissue remodeling and renewal.