Neuropilin 1 Recombinant Rabbit Monoclonal Antibody [ST05-30] (ET1609-69)

UNIPROT #

O14786

PROTEIN NAME

Neuropilin 1

SYNONYMS

A5 protein antibody;BDCA4 antibody;BLOOD DENDRITIC CELL ANTIGEN 4 antibody;CD304 antibody;Neuropilin-1 antibody;Neuropilin1 antibody;NP1 antibody;NPN1 antibody;NRP 1 antibody;NRP antibody;NRP1 antibody;NRP1_HUMAN antibody;transmembrane receptor antibody;Vascular endothelial cell growth factor 165 receptor antibody;VEGF165R antibody

SEQUENCE SIMILARITIES

Belongs to the neuropilin family.

TISSUE SPECIFICITY

The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules.

SUBCELLULAR LOCATION

Cell membrane, Secreted.

FUNCTION

Neuropilin is a type I transmembrane receptor that has been implicated in aspects of axon growth and guidance and has been shown to act as a high affinity receptor for class III semaphorins and vascular endothelial growth factor (VEGF). A closely related protein, neuropilin-2, shares a common domain structure and signifcant homology with neuropilin and also acts as a receptor for the class III semaphorins and VEGF. Both neuropilins are involved in regulating many physiological pathways including axonal guidance and angiogenesis, however they exhibit differential expression in the adult vasculature. Neuropilin-2 is polysialylated and expressed on the surface of dendritic cells. It is also expressed by venous and lymphatic endothelium. Neuropilin is expressed predominantly by arterial endothelium.