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Phospho-IRE1 (S724) Recombinant Rabbit Monoclonal Antibody [PSH03-35] (HA721980)

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Catalog# HA721980

Rabbit Monoclonal to Phospho-IRE1 (S724)

Tested for

  • WB

  • IF-Cell

  • IHC-P

  • FC

Reacts with

  • Human

  • Mouse

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free

Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

Phospho-IRE1 (S724) Recombinant Rabbit Monoclonal Antibody [PSH03-35] (HA721980)

Immunogen

Synthetic phospho-peptide corresponding to residues surrounding ser724 of human ire1.

Host

Rabbit

Modification

Phospho

Modification Site

S724

Positive Control

HeLa starved for 3 hours then treated with 100nM Calyculin A for 30 minutes cell lysate, Jurkat treated with 100nM Calyculin A for 30 minutes cell lysate, Jurkat cells treated with 100nM Calyculin A for 30 minutes, human pancreas tissue, HeLa cells treated with 100nM Calyculin A for 30 minutes.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

PSH03-35

RRID

AB_3096844

APPLICATION DILUTION

  • WB

  • 1:1,000

  • IF-Cell

  • 1:500

  • IHC-P

  • 1:500

  • FC

  • 1:1,000

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 110 kDa

Isotype

IgG

TARGET

UNIPROT #

O75460

PROTEIN NAME

Phospho-IRE1 (S724)

SYNONYMS

Endoplasmic reticulum (ER) to nucleus signalling 1 antibody;Endoplasmic reticulum to nucleus signaling 1 antibody;Endoplasmic reticulum-to-nucleus signaling 1 antibody;Endoribonuclease antibody;ER to nucleus signaling 1 antibody;ERN 1 antibody;Ern1 antibody;ERN1_HUMAN antibody;hIRE 1p antibody;hIRE1p antibody;Inositol requiring 1 antibody;Inositol requiring 1, S. cerevisiae, homolog of antibody;Inositol requiring enzyme 1, S. cerevisiae, homolog of antibody;Inositol requiring protein 1 antibody;inositol-requiring enzyme 1 antibody;Inositol-requiring protein 1 antibody;IRE 1 antibody;IRE 1a antibody;IRE 1P antibody;Ire1 alpha antibody;Ire1-alpha antibody;IRE1a antibody;Ire1alpha antibody;IRE1P antibody;MGC163277 antibody;MGC163279 antibody;Protein kinase/endoribonuclease antibody;RGD1559716 antibody;Serine/threonine protein kinase/endoribonuclease IRE1 antibody

SUBCELLULAR LOCATION

Endoplasmic reticulum membrane; nucleus.

FUNCTION

The serine/threonine-protein kinase/endoribonuclease inositol-requiring enzyme 1 α (IRE1α) is an enzyme that in humans is encoded by the ERN1 gene. The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals (mainly the unfolded protein response). Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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