Biotin Conjugated Human IL-33 Recombinant Rabbit Monoclonal Antibody [PSH03-06] (HA722628B)

UNIPROT #

O95760

PROTEIN NAME

Human IL-33

SYNONYMS

C9orf26 antibody;CHROMOSOME 9 OPEN READING FRAME 26 antibody;DKFZp586H0523 antibody;DVS27 antibody;DVS27 related protein antibody;IL 1F11 antibody;IL 33 antibody;IL-1F11 antibody;IL-33 antibody;IL1F11 antibody;IL33 antibody;IL33_HUMAN antibody;Interleukin 1 family member 11 antibody;Interleukin 33 antibody;INTERLEUKIN 33 NFHEV antibody;Interleukin 33 precursor antibody;Interleukin-1 family member 11 antibody;Interleukin-33 (109-270) antibody;Interleukin33 antibody;NF HEV antibody;NF-HEV antibody;NFEHEV antibody;NFHEV antibody;Nuclear factor for high endothelial venules antibody;Nuclear factor from high endothelial venules antibody;OTTHUMP00000021041 antibody;RP11 575C20.2 antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury. Induces rapid UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages. In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets.