Glutamine Synthetase Mouse Monoclonal Antibody

Function

The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency, and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2, 5, 9, 11, and 12. Alternative splicing results in multiple transcript variants.

Background References

1. Muthu M. et. al. GLUL Ablation Can Confer Drug Resistance to Cancer Cells via a Malate-Aspartate Shuttle-Mediated Mechanism. Cancers (Basel). 2019 Dec

2. Wang Y. et. al. GLUL Promotes Cell Proliferation in Breast Cancer. J Cell Biochem. 2017 Aug

Subcellular Location

Microsome, Cytosol, Mitochondrion, Cell membrane.

UNIPROT

SwissProt: P15104 Human

Synonyms