Human APOC3, Tag Free Protein
Catalog# HA211274
Human APOC3, Tag Free Protein
Product Information
Product name
Human APOC3, Tag Free Protein
Catalog No.
HA211274
Predicted molecular mass
10.8 kD
Protein construction description
A DNA sequence encoding the human APOC3 protein (P02656) (Ser 21-Ala 99) was expressed with tag free.
Accession
P02656
Protein construction
Source
HEK293
Bio Activity
Testing in progress.
Purity
>95% as determined by SDS-PAGE.
Endotoxin
Less than 1.0 EU per μg by the LAL method.
Formulation
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
Species
Human
Background
Apolipoprotein C-III also known as apo-CIII, and apolipoprotein C3, is a protein that in humans is encoded by the APOC3 gene. Apo-CIII is secreted by the liver as well as the small intestine, and is found on triglyceride-rich lipoproteins such as chylomicrons, very low density lipoprotein (VLDL), and remnant cholesterol. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to inhibit hepatic uptake of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. Recent evidence suggests an intracellular role for Apo-CIII in promoting the assembly and secretion of triglyceride-rich VLDL particles from hepatic cells under lipid-rich conditions. However, two naturally occurring point mutations in human apoC3 coding sequence, namely Ala23Thr and Lys58Glu have been shown to abolish the intracellular assembly and secretion of triglyceride-rich VLDL particles from hepatic cells.
Usage guide
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.
Storage
Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
Reconstitution
Reconstitute at 250 μg/ml in sterile water.
Products with the same target and pathway
Human IL1RL1/DER4/ST2, C-His (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human TGF-alpha, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Cardiotrophin-1/CT-1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human FABP3 / H-FABP, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-6, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Alpha-fetoprotein, C-His Tag
Application:
Reactivity: Human
Conjugate:
Human VEGF-C, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Antithrombin III, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CXCL10, C-Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Leptin Receptor, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human Neuropeptide Y (29-64 peptide) Protein
Application:
Reactivity: Human
Conjugate:
Human SAA1, C-Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Apolipoprotein E, Tag Free
Application:
Reactivity: Human
Conjugate:
Human EPCR/PROCR/CD201, C-His, Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL-18, Tag Free (HEK293) Protein
Application:
Reactivity: Human
Conjugate:
Human ACE2, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human LDLR/LDL Receptor, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-18, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Peroxiredoxin 6/PRDX6, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Sorcin/SRI, N-Twin Strep, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human AGRP, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-33, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human ACE, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Lipocalin-2/NGAL, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human GHRL, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human HBEGF, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human FGF Basic/FGF2, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL1RL1/DER4/ST2, C-hFc, His (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human Clusterin, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human E-Selectin/CD62E, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL-17F, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Pro-neuropeptide Y, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Fetuin A/AHSG, Tag Freee Protein
Application:
Reactivity: Human
Conjugate:
Human Ficolin-2, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Angiogenin, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human VEGF165, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CALCA, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human HGF, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Serpin A1/Alpha-1-antitrypsin, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-8/CXCL8 Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CKMB heterodimer, C-Flag, StrepII Tag&C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Apolipoprotein E/APOE4 (C130R), Tag Free
Application:
Reactivity: Human
Conjugate:
Human HGF, C-Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human tPA, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Angiotensinogen, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Renin, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Transthyretin/TTR, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Haptoglobin/HP, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Apolipoprotein A-I/APOA1, Tag Free
Application:
Reactivity: Human
Conjugate:
Human LAP3, C-His Tag (Isoform 2) Protein
Application:
Reactivity: Human
Conjugate:
Human Human LOX-1/OLR1,C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human FABP7/B-FABP, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human RBP4, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human G-CSF, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IMMT/Mitofilin, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CASQ2, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human FGF2/b-FGF, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CKM, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human PDGF-B, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human VEGF121, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human TNF RII/TNFRSF1B, C-His (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IP-10/CXCL10, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Leptin, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Periostin/OSF-2, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CCL2/MCP1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human MMP1, C-Flag Protein
Application:
Reactivity: Human
Conjugate:
Human Adiponectin/Acrp30, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Beta-2-microglobulin/B2M, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human VE-cadherin, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human LILRB4/ILT3, C-His, Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL-6, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human TIE2/TEK, C-His, Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human Pentraxin 3/PTX3, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human A2M/alpha-2-macroglobulin, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Resistin, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human VEGFR2/KDR, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
