Human IL-33, C-His Tag Protein
Catalog# HA210539
Human IL-33, C-His Tag Protein
Product Information
Product name
Human IL-33, C-His Tag Protein
Catalog No.
HA210539
Predicted molecular mass
20 kD
Protein construction description
A DNA sequence encoding the human IL-33 protein (O95760) (His 109-Thr 270) was expressed with a His tag at the C-terminus.
Accession
O95760
Protein construction
IL-33 (109-270)
His
Source
E.coli
Bio Activity
Testing in progress.
Purity
>95% as determined by SDS-PAGE.
Endotoxin
Less than 1.0 EU per μg by the LAL method.
Formulation
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
Species
Human
Background
Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury. Induces rapid UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages. In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets.
Usage guide
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.
Storage
Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
Reconstitution
Reconstitute at 250 μg/ml in sterile water.
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Human Neuropilin-1/NRP1, C-His Tag (ECD) Protein
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Reactivity: Human
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Reactivity: Human
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Reactivity: Human
Conjugate:
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Reactivity: Human
Conjugate:
Human CD31/PECAM-1, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human P-Selectin/CD62P, C-His Tag (ECD) Protein
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Reactivity: Human
Conjugate:
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Reactivity: Human
Conjugate:
Human Beta-2-microglobulin/B2M, C-His Tag Protein
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Reactivity: Human
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Human IL12B/P40, C-His Tag Protein
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Reactivity: Human
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Human PD-1, C-His Tag Protein
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Reactivity: Human
Conjugate:
Human VCAM-1 / CD106, C-His Tag Protein
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Reactivity: Human
Conjugate:
Human VE-cadherin, Tag Free (ECD) Protein
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Reactivity: Human
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Human LILRB4/ILT3, C-His, Flag Tag (ECD) Protein
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Reactivity: Human
Conjugate:
Human IL-18 BPa, C-His Tag Protein
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Reactivity: Human
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Reactivity: Human
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Human CD207, C-Flag Tag Protein
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Reactivity: Human
Conjugate:
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Reactivity: Human
Conjugate:
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Reactivity: Human
Conjugate:
Human B7-DC/PD-L2/CD273, C-Flag Tag (ECD) Protein
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Reactivity: Human
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Reactivity: Human
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Reactivity: Human
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Reactivity: Human
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Reactivity: Human
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Reactivity: Human
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Reactivity: Human
Conjugate:
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Reactivity: Human
Conjugate:
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Reactivity: Human
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Reactivity: Human
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Reactivity: Human
Conjugate:
Human VEGFR2/KDR, Tag Free (ECD) Protein
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Reactivity: Human
Conjugate:
Human IFN-gamma R1, C-His Tag (ECD) Protein
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Reactivity: Human
Conjugate:
Human Interferon alpha-2/IFNA2, C-His Tag Protein
Application:
Reactivity: Human
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