Human FGF R3 (IIIc)/FGF R3C/CD333, C-His Tag Protein

Usd: 129

Specification

20μg

50μg

100μg

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Catalog# HA211488

Human FGF R3 (IIIc)/FGF R3C/CD333, C-His Tag Protein

Product Information

Product name

Human FGF R3 (IIIc)/FGF R3C/CD333, C-His Tag Protein

Catalog No.

HA211488

Predicted molecular mass

39.9 kD

Protein construction description

A DNA sequence encoding the human FGF R3 (IIIc) / FGF R3C / CD333 protein (P22607-1) (Glu 23-Gly 375) was expressed with a His tag at the C-terminus.

Accession

P22607-1

Protein construction

FGF R3 (IIIc) / FGF R3C / CD333 (23-375) His

Source

HEK293

Bio Activity

Testing in progress.

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.

Species

Human

Background

Acidic and basic fibroblast growth factors (FGFs) are members of a family of multifunctional polypeptide growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. Like other growth factors, FGFs act by binding and activating specific cell surface receptors. These include the Flg receptor or FGFR-1, the Bek receptor or FGFR-2, FGFR-3, FGFR-4, FGFR-5 and FGFR-6. These receptors usually contain an extracellular ligand-binding region containing three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The gene encoding human FGFR-3 maps to chromosome 4p16 and is alternatively spliced to produce three isoforms that are expressed in brain, kidney and testis. Defects in FGFR-3 are associated with several diseases, including Crouzon syndrome, achondroplasia, thanatophoric dysplasia, craniosynostosis adelaide type and hypochondroplasia. Mutations in FGFR-3 are also a cause of some bladder and cervical cancers.

Usage guide

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.

Storage

Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.