Human IL-6R, C-His (ECD) Protein
Catalog# HA210640
Human IL-6R, C-His (ECD) Protein
Product Information
Product name
Human IL-6R, C-His (ECD) Protein
Catalog No.
HA210640
Predicted molecular mass
39.9 kD
Protein construction description
A DNA sequence encoding the human IL-6R protein (P08887) (Leu 20-Pro 365) was expressed with a His tag at the C-terminus.
Accession
P08887
Protein construction
IL-6R (20-365)
His
Source
HEK293
Bio Activity
Testing in progress.
Purity
>95% as determined by SDS-PAGE.
Endotoxin
Less than 1.0 EU per μg by the LAL method.
Formulation
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
Species
Human
Background
Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis. The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system. Whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.
Usage guide
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.
Storage
Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
Reconstitution
Reconstitute at 250 μg/ml in sterile water.
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Reactivity: Human
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Reactivity: Human
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Reactivity: Human
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Reactivity: Human
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Human B7-DC/PD-L2/CD273, C-Flag Tag (ECD) Protein
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Reactivity: Human
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Human IL-6, C-His Tag Protein
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Reactivity: Human
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Human GADD45A, N-Twin Strep, C-His, Flag Tag Protein
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Reactivity: Human
Conjugate:
Human TIE2/TEK, C-His, Flag Tag (ECD) Protein
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Reactivity: Human
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Reactivity: Human
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Human GH1, C-His Tag Protein
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Reactivity: Human
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Human DPP-4/CD26/DPPIV, C-His Tag (ECD) Protein
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Reactivity: Human
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Reactivity: Human
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Human CD14, C-His Tag Protein
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Reactivity: Human
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