Human GITR Ligand/TNFSF18, Tag Free Protein
Catalog# HA211265
Human GITR Ligand/TNFSF18, Tag Free Protein
Product Information
Product name
Human GITR Ligand/TNFSF18, Tag Free Protein
Catalog No.
HA211265
Predicted molecular mass
15.4 kD
Protein construction description
A DNA sequence encoding the human GITR Ligand/TNFSF18 protein (Q9UNG2) (Leu 49-Ser 177) was expressed with tag free.
Accession
Q9UNG2
Protein construction
GITR Ligand/TNFSF18 (49-177)
Source
HEK293
Bio Activity
Testing in progress.
Purity
>95% as determined by SDS-PAGE.
Endotoxin
Less than 1.0 EU per μg by the LAL method.
Formulation
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
Species
Human
Background
Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. Promotes leukocyte adhesion to endothelial cells. Regulates migration of monocytes from the splenic reservoir to sites of inflammation.
Usage guide
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.
Storage
Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
Reconstitution
Reconstitute at 250 μg/ml in sterile water.
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