Human TLR3, C-His Tag Protein
Catalog# HA211381
Human TLR3, C-His Tag Protein
Product Information
Product name
Human TLR3, C-His Tag Protein
Catalog No.
HA211381
Predicted molecular mass
78.4 kD
Protein construction description
A DNA sequence encoding the human TLR3 protein (O15455-1) (Lys 27-Ala 700) was expressed with a His tag at the C-terminus.
Accession
O15455-1
Protein construction
TLR3 (27-700)
His
Source
HEK293
Bio Activity
Testing in progress.
Purity
>95% as determined by SDS-PAGE.
Endotoxin
Less than 1.0 EU per μg by the LAL method.
Formulation
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
Species
Human
Background
Toll-like receptor 3 (TLR3) also known as CD283 (cluster of differentiation 283) is a protein that in humans is encoded by the TLR3 gene. TLR3 is a member of the toll-like receptor family of pattern recognition receptors of the innate immune system. TLR3 recognizes double-stranded RNA in endosomes, which is a common feature of viral genomes internalised by macrophages and dendritic cells. TLR3 is a member of the toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of IRF3 and NF-κB. Unlike other TLRs, TLR3 uses TRIF as the sole adaptor. IRF3 ultimately induces the production of type I interferons. It may thus play a role in host defense against viruses.
Usage guide
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.
Storage
Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
Reconstitution
Reconstitute at 250 μg/ml in sterile water.
Products with the same target and pathway
Human IL1RL1/DER4/ST2, C-His (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL-5, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Beta-NGF, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human LBP, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human TAG1/Contactin 2/CNTN2, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human GTPase HRAS, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human MCP-3/CCL7, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Interferon omega-1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human TGF-alpha, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CCL21/6Ckine, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-9, C-Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-1 beta/IL1B, Tag Free (pro form) Protein
Application:
Reactivity: Human
Conjugate:
Human PRDM1, N-Twin Strep, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-6, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CCL19 / MIP-3 beta, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human SIRPA, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CCL17/TARC, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human TRAIL/TNFSF10, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CD48, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CD30 Ligand / TNFSF8, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IKK gamma/NEMO, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-22, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Insulin, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-17C, C-hFc Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CCL3/MIP-1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CCL16/LEC, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human TNF RI/TNFRSF1A, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CXCL10, C-Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Leptin Receptor, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL-7, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-7 R alpha / CD127, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human DR3/TNFRSF25, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CCL11/Eotaxin, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-2, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CXCL5, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human ULBP1/NKG2DL1, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human EGFR, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IFN-gamma, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human APP, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human LAIR1, N-Twin Strep, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human EPCR/PROCR/CD201, C-His, Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human ICAM-3/CD50, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human MCP-2/CCL8, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CD40/TNFRSF5, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-18, Tag Free (HEK293) Protein
Application:
Reactivity: Human
Conjugate:
Human BAFF/BLyS/TNFSF13B, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human OX40/TNFRSF4, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-18, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human TRAF3, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CDCP1/CD318, N-Twin Strep, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human 5'-nucleotidase/CD73/NT5E, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CXCL13 / BCA-1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human c-Fos, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Neuropilin-1/NRP1, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human LAMP3/CD208, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-36 gamma/IL-1 F9, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human TREM1, C-Hia, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human LILRB2/CD85d/ILT4, C-His, Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CSK, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL1R1, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human LIGHT/TNFSF14, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human DR3/TNFRSF25, hFc Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CD2, N-Twin Strep, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-33, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-17A, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human beta-NGF, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CD155/PVR, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human ACE, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IFN-alpha/beta R2, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL-3, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human TNF-alpha, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL12RB1, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human ICOS Ligand/B7-H2/ICOSLG, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CXCL2/GRO beta, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Siglec-3/CD33, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human FGFR2, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CEACAM-5/CD66e, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Syndecan-1/CD138, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human ICAM-2/CD102, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL5RA, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CSF3R/G-CSFR/CD114, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL17RA/CD217, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL1RL1/DER4/ST2, C-hFc, His (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL-13 R alpha 2/IL13RA2, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human E-Selectin/CD62E, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human Endoglin/CD105, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CD47, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human Fas/TNFRSF6/CD95, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL-21, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-25/IL-17E, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CXCL6/GCP-2, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human N-Cadherin, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-17F, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CCL27, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CD155/PVR, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CD163, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human M-CSFR/CSF1R/CD115, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human TNFSF11/RANKL/CD254, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human L-selectin/CD62L, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human HCLS1, N-Strep II, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-10RB, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL1RA, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-1 RII, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CD30/TNFRSF8, C-His, Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human Nectin-2, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CD83, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Fractalkine/CX3CL1, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CXCL11/I-TAC, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CEACAM-1/CD66a, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CD200, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CCL25/TECK, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-8/CXCL8 Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human LAG-3, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CD40 Ligand/TNFSF5, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CD147/Basigin/EMMPRIN, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-10, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human B7-1/CD80, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CCL5/RANTES, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CCL26/Eotaxin-3, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CCL20, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human TNF-alpha, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-3R alpha/CD123, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-7, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CDC42, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human uPAR/PLAUR, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-13, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CD28, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human MAPK12, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IFN-alpha/beta R1, C-His (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CD58/LFA-3, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL-21, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human RAC1, C-Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-31, C-Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human BST2/Tetherin, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CD46, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CD117/c-Kit, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human TACI/TNFRSF13B, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-20, C-hFc Tag Protein
Application:
Reactivity: Human
Conjugate:
Human NKp46/NCR1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human GITR Ligand/TNFSF18, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human NKG2D, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CCL22 / MDC, C-hFc Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CD70/CD27 Ligand/TNFSF7, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-2R alpha, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-2RB/CD122, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IFN-gamma, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human 4-1BB/TNFRSF9, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Siglec-7/CD328, C-His (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL-1 beta/IL1B, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human EGF, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-10, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-4, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-2, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human HVEM/TNFRSF14, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human ICAM-1/CD54, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human PD-L1/B7-H1, C-hFc Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-16, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human TNF RII/TNFRSF1B, C-His (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human PD-L1/B7-H1, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human B7-H3, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL-29/IFN-lambda 1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Osteoprotegerin / TNFRSF11B, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CD272/BTLA, C-His, Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human HVEM/TNFRSF14, C-Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human MAPK6, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CD5, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IP-10/CXCL10, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CXCL12/SDF-1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CD27/TNFRSF7, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human LILRB1/CD85j/ILT2, C-His, Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human GITR/TNFRSF18/AITR, C-Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CD2, C-His, Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL-1 alpha/IL1A, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-4R, C-His, Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CXCL9, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CCL2/MCP1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CTLA-4, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CD31/PECAM-1, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human P-Selectin/CD62P, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL12B/P40, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human PD-1, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human VCAM-1 / CD106, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human VE-cadherin, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human LILRB4/ILT3, C-His, Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL-18 BPa, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CD63, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CD207, C-Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human ANPEP/CD13, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CXCL1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human B7-DC/PD-L2/CD273, C-Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL-6, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-6R, C-His (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human GADD45A, N-Twin Strep, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human TIE2/TEK, C-His, Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human NCAM1/CD56, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human DPP-4/CD26/DPPIV, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CD14, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CYLD, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL2RG/CD132, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human E-Cadherin, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human TIMP1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human VEGFR2/KDR, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IFN-gamma R1, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
