Human IL-16, C-His Tag Protein

Usd: 159

Specification

20μg

50μg

100μg

Bulk Order Quote | Customization Request

Catalog# HA210917

Human IL-16, C-His Tag Protein

Product Information

Product name

Human IL-16, C-His Tag Protein

Catalog No.

HA210917

Predicted molecular mass

14.8 kD

Protein construction description

A DNA sequence encoding the human IL-16 protein (Q14005-1) (Met 1203-Ser 1332) was expressed with a His tag at the C-terminus

Accession

Q14005-1

Protein construction

IL-16 (1203-1332) His

Source

HEK293

Bio Activity

Testing in progress.

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.

Species

Human

Background

The cytokine encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. Interleukin 16 (IL-16) is released by a variety of cells (including lymphocytes and some epithelial cells) that has been characterized as a chemoattractant for certain immune cells expressing the cell surface molecule CD4. IL-16 was originally described as a factor that could attract activated T cells in humans, it was previously called lymphocyte chemoattractant factor (LCF). Since then, this interleukin has been shown to recruit and activate many other cells expressing the CD4 molecule, including monocytes, eosinophils, and dendritic cells. The structure of IL-16 was determined following its cloning in 1994. This cytokine is produced as a precursor peptide (pro-IL-16) that requires processing by an enzyme called caspase-3 to become active. CD4 is the cell signaling receptor for mature IL-16.

Usage guide

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.

Storage

Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.

Reconstitution

Reconstitute at 250 μg/ml in sterile water.

Human IL-16, C-His Tag Protein

Usd: 159

Specification

Product Information

Product name

Catalog No.

Predicted molecular mass

Protein construction description

Accession

Protein construction

Source

Bio Activity

Purity

Endotoxin

Formulation

Species

Background

Usage guide

Shipping

Storage

Reconstitution

Products with the same target and pathway

Human IL1RL1/DER4/ST2, C-His (ECD) Protein

Application:

Reactivity: Human

Conjugate:

Human IL-5, C-His Tag Protein

Application:

Reactivity: Human

Conjugate:

Human IL-9, C-Flag Tag Protein

Application:

Reactivity: Human

Conjugate:

Human PRDM1, N-Twin Strep, C-His, Flag Tag Protein

Application:

Reactivity: Human

Conjugate:

Human IL-6, Tag Free Protein

Application:

Reactivity: Human

Conjugate:

Human CCL17/TARC, Tag Free Protein

Application:

Reactivity: Human

Conjugate:

Human TRAIL/TNFSF10, C-His Tag Protein

Application:

Reactivity: Human

Conjugate:

Human CD48, C-His Tag Protein

Application:

Reactivity: Human

Conjugate:

Human IL-22, C-His, Flag Tag Protein

Application:

Reactivity: Human

Conjugate:

Human CCL3/MIP-1, Tag Free Protein

Application:

Reactivity: Human

Conjugate:

Human TNF RI/TNFRSF1A, Tag Free (ECD) Protein

Application:

Reactivity: Human

Conjugate:

Human CXCL10, C-Flag Tag Protein

Application:

Reactivity: Human

Conjugate:

Human IL-7, C-His, Flag Tag Protein

Application:

Reactivity: Human

Conjugate:

Human CCL11/Eotaxin, Tag Free Protein

Application:

Reactivity: Human

Conjugate:

Human IL-2, C-His Tag Protein

Application: