Human IL-2, C-His Tag Protein
Catalog# HA210670
Human IL-2, C-His Tag Protein
Product Information
Product name
Human IL-2, C-His Tag Protein
Catalog No.
HA210670
Predicted molecular mass
16.8 kD
Protein construction description
A DNA sequence encoding the human IL-2 protein (P60568) (Ala 21-Thr 153) was expressed with a His tag at the C-terminus.
Accession
P60568
Protein construction
IL-2 (21-153)
His
Source
HEK293
Bio Activity
Testing in progress.
Purity
>95% as determined by SDS-PAGE.
Endotoxin
Less than 1.0 EU per μg by the LAL method.
Formulation
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
Species
Human
Background
ytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well.
Usage guide
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.
Storage
Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
Reconstitution
Reconstitute at 250 μg/ml in sterile water.
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Human Neuropilin-1/NRP1, C-His Tag (ECD) Protein
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Reactivity: Human
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Reactivity: Human
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Reactivity: Human
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Reactivity: Human
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Reactivity: Human
Conjugate:
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Reactivity: Human
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Human LILRB4/ILT3, C-His, Flag Tag (ECD) Protein
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Reactivity: Human
Conjugate:
Human IL-18 BPa, C-His Tag Protein
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Reactivity: Human
Conjugate:
Human CD63, Tag Free (ECD) Protein
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Reactivity: Human
Conjugate:
Human CD207, C-Flag Tag Protein
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Reactivity: Human
Conjugate:
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Reactivity: Human
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Reactivity: Human
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Human B7-DC/PD-L2/CD273, C-Flag Tag (ECD) Protein
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Reactivity: Human
Conjugate:
Human IL-6, C-His Tag Protein
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Reactivity: Human
Conjugate:
Human IL-6R, C-His (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human GADD45A, N-Twin Strep, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human TIE2/TEK, C-His, Flag Tag (ECD) Protein
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Reactivity: Human
Conjugate:
Human NCAM1/CD56, Tag Free (ECD) Protein
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Reactivity: Human
Conjugate:
Human Fibronectin/FN1, Tag Free Protein
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Reactivity: Human
Conjugate:
Human GH1, C-His Tag Protein
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Reactivity: Human
Conjugate:
Human DPP-4/CD26/DPPIV, C-His Tag (ECD) Protein
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Reactivity: Human
Conjugate:
Human PDGF-AA, Tag Free Protein
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Reactivity: Human
Conjugate:
Human CD14, C-His Tag Protein
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Reactivity: Human
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Human CYLD, C-His Tag Protein
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Reactivity: Human
Conjugate:
Human FGF7, Tag Free Protein
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Reactivity: Human
Conjugate:
Human IL2RG/CD132, C-His Tag (ECD) Protein
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Reactivity: Human
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Human E-Cadherin, C-His Tag (ECD) Protein
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Reactivity: Human
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Reactivity: Human
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Reactivity: Human
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Reactivity: Human
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