Human IL-18, Tag Free Protein
Catalog# HA210779
Human IL-18, Tag Free Protein
Product Information
Product name
Human IL-18, Tag Free Protein
Catalog No.
HA210779
Predicted molecular mass
18.6 kD
Protein construction description
A DNA sequence encoding the human Il-18 protein (Q14116-1) (Tyr 37-Asp 193) was expressed with tag free.
Accession
Q14116-1
Protein construction
IL-18 (37-193)
Source
E.coli
Bio Activity
Testing in progress.
Purity
>95% as determined by SDS-PAGE.
Endotoxin
Less than 1.0 EU per μg by the LAL method.
Formulation
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
Species
Human
Background
Interleukin-18 (IL-18), also known as interferon-gamma inducing factor is a protein which in humans is encoded by the IL18 gene. The protein encoded by this gene is a proinflammatory cytokine. Many cell types, both hematopoietic cells and non-hematopoietic cells, have the potential to produce IL-18. It was first described in 1989 as a factor that induced interferon-γ (IFN-γ) production in mouse spleen cells. Originally, IL-18 production was recognized in Kupffer cells, liver-resident macrophages. However, IL-18 is constitutively expressed in non-hematopoietic cells, such as intestinal epithelial cells, keratinocytes, and endothelial cells. IL-18 can modulate both innate and adaptive immunity and its dysregulation can cause autoimmune or inflammatory diseases. IL-18 belongs to the IL-1 superfamily and is produced mainly by macrophages but also other cell types, stimulates various cell types and has pleiotropic functions. IL-18 is a proinflammatory cytokine that facilitates type 1 responses. Together with IL-12, it induces cell-mediated immunity following infection with microbial products like lipopolysaccharide (LPS). IL-18 in combination with IL12 acts on CD4, CD8 T cells and NK cells to induce IFNγ production, type II interferon that plays an important role in activating the macrophages or other cells. The combination of this IL-18 and IL-12 has been shown to inhibit IL-4 dependent IgE and IgG1 production and enhance IgG2a production in B cells. Importantly, without IL-12 or IL-15, IL-18 does not induce IFNγ production, but plays an important role in the differentiation of naive T cells into Th2 cells and stimulates mast cells and basophils to produce IL-4, IL-13, and chemical mediators such as histamine.
Usage guide
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.
Storage
Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
Reconstitution
Reconstitute at 250 μg/ml in sterile water.
Products with the same target and pathway
Human IL1RL1/DER4/ST2, C-His (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL-5, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human PAI-1/Serpin E1, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-9, C-Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human PRDM1, N-Twin Strep, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-6, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Alpha-fetoprotein, C-His Tag
Application:
Reactivity: Human
Conjugate:
Human MMP12, C-Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CCL17/TARC, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human TRAIL/TNFSF10, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CD48, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-22, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human VEGF-C, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CCL3/MIP-1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Antithrombin III, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human TNF RI/TNFRSF1A, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CXCL10, C-Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-7, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Erythropoietin/EPO, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CCL11/Eotaxin, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-2, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CXCL5, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human SAA1, C-Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human ULBP1/NKG2DL1, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Mesothelin/MSLN, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human LAIR1, N-Twin Strep, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human EPCR/PROCR/CD201, C-His, Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human BAFF/BLyS/TNFSF13B, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human ACE2, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human OX40/TNFRSF4, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human TRAF3, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CDCP1/CD318, N-Twin Strep, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human 5'-nucleotidase/CD73/NT5E, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Sorcin/SRI, N-Twin Strep, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human M-CSF/CSF1 (33-255), C His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Neuropilin-1/NRP1, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human TREM1, C-Hia, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human LILRB2/CD85d/ILT4, C-His, Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CSK, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CD2, N-Twin Strep, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-33, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-17A, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CD155/PVR, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IFN-alpha/beta R2, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL-3, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human TNF-alpha, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Lipocalin-2/NGAL, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL12RB1, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human ICOS Ligand/B7-H2/ICOSLG, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CXCL2/GRO beta, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Siglec-3/CD33, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Osteopontin/OPN, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human GHRL, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human MMP8/CLG1, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Angiopoietin-1/ANGPT1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Syndecan-1/CD138, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human FGF Basic/FGF2, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL5RA, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human MMP13, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL17RA/CD217, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL1RL1/DER4/ST2, C-hFc, His (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human Clusterin, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-13 R alpha 2/IL13RA2, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human E-Selectin/CD62E, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human Endoglin/CD105, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL-17F, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human HCLS1, N-Strep II, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Angiogenin, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL1RA, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Enolase 2/ENO2, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-1 RII, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CD30/TNFRSF8, C-His, Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human LTA, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CCL3L1, N-Twin Strep, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human VEGF165, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-15, C-Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CALCA, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Nectin-2, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human HGF, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human M-CSF/CSF1 (33-190), Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CEACAM-1/CD66a, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human GM-CSF, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CD200, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CCL25/TECK, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-8/CXCL8 Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human LAG-3, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CD40 Ligand/TNFSF5, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CKMB heterodimer, C-Flag, StrepII Tag&C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CD147/Basigin/EMMPRIN, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Apolipoprotein E/APOE4 (C130R), Tag Free
Application:
Reactivity: Human
Conjugate:
Human IL-10, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IFNA1/IFNA13, C-Tag Protein
Application:
Reactivity: Human
Conjugate:
Human HGF, C-Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human B7-1/CD80, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CCL5/RANTES, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human tPA, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CCL20, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human TNF-alpha, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-3R alpha/CD123, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-7, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CDC42, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-13, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CD28, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Mesothelin, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human MAPK12, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IFN-alpha/beta R1, C-His (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CD58/LFA-3, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL-21, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human RAC1, C-Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-31, C-Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-2R alpha, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-2RB/CD122, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IFN-gamma, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human 4-1BB/TNFRSF9, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Siglec-7/CD328, C-His (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human RBP4, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human G-CSF, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IMMT/Mitofilin, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CASQ2, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-1 beta/IL1B, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human FGF2/b-FGF, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human MMP-7, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Osteoactivin/GPNMB, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human EGF, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-10, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-4, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CKM, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-2, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human HVEM/TNFRSF14, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human ICAM-1/CD54, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human PDGF-B, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human PD-L1/B7-H1, C-hFc Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-16, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human VEGF121, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human TNF RII/TNFRSF1B, C-His (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human PD-L1/B7-H1, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human B7-H3, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL-29/IFN-lambda 1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Osteoprotegerin / TNFRSF11B, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CD272/BTLA, C-His, Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human HVEM/TNFRSF14, C-Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human MAPK6, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human TOPBP1, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CD5, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human MMP3, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IP-10/CXCL10, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CXCL12/SDF-1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human ACP3/ACPP, C His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CD27/TNFRSF7, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human LILRB1/CD85j/ILT2, C-His, Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human GITR/TNFRSF18/AITR, C-Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human Leptin, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CD2, C-His, Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL-1 alpha/IL1A, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human cIAP-2/BIRC3, N-Twin Strep, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Periostin/OSF-2, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-4R, C-His, Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CXCL9, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CCL2/MCP1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CTLA-4, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CD31/PECAM-1, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human MMP1, C-Flag Protein
Application:
Reactivity: Human
Conjugate:
Human P-Selectin/CD62P, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human Adiponectin/Acrp30, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Beta-2-microglobulin/B2M, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL12B/P40, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human PD-1, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human VCAM-1 / CD106, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human VE-cadherin, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human LILRB4/ILT3, C-His, Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL-18 BPa, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CD63, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CD207, C-Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human ANPEP/CD13, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CXCL1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human ACP1, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human B7-DC/PD-L2/CD273, C-Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL-6, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-6R, C-His (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human GADD45A, N-Twin Strep, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human TIE2/TEK, C-His, Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human Pentraxin 3/PTX3, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human A2M/alpha-2-macroglobulin, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human MMP-9, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human NCAM1/CD56, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human Fibronectin/FN1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human DPP-4/CD26/DPPIV, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CD14, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CYLD, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL2RG/CD132, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human E-Cadherin, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human TIMP1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human MMP2/CLG4A, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Resistin, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human VEGFR2/KDR, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IFN-gamma R1, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human Interferon alpha-2/IFNA2, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Carbonic Anhydrase XII/CA12, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
