Human Leptin, Tag Free Protein
Catalog# HA210961
Human Leptin, Tag Free Protein
Product Information
Product name
Human Leptin, Tag Free Protein
Catalog No.
HA210961
Predicted molecular mass
16.4 kD
Protein construction description
A DNA sequence encoding the human Leptin protein (P41159) (Val 22-Cys 167) was expressed with tag free.
Accession
P41159
Protein construction
Leptin (22-167)
Source
HEK293
Purity
>95% as determined by SDS-PAGE.
Endotoxin
Less than 1.0 EU per μg by the LAL method.
Formulation
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
Species
Human
Background
Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity. In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides. In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption.
Usage guide
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.
Storage
Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
Reconstitution
Reconstitute at 250 μg/ml in sterile water.
Products with the same target and pathway
Human Angiogenin, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human APOC3, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human TGF-alpha, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Haptoglobin/HP, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Neuropeptide Y (29-64 peptide)
Application:
Reactivity: Human
Conjugate:
Human SAA1, C-Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Thrombospondin-1/THBS1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Insulin, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human ACE, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human TNNI3, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human HBEGF, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human LAP3, C-His Tag (Isoform 2) Protein
Application:
Reactivity: Human
Conjugate:
Human Thrombomodulin, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human PLGF/PGF, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Ferritin heavy chain 1/FTH1, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Chemerin/RARRES2, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Procalcitonin/CALCA, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human VEGF-C, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human RBP4, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human FGL1, C-hFc Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Serpin A1/Alpha-1-antitrypsin, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Bikunin/AMBP, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human NT-proBNP, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human proBNP, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Clusterin, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Apolipoprotein E, Tag Free
Application:
Reactivity: Human
Conjugate:
Human GATA4, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-8/CXCL8 Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human LDLR/LDL Receptor, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CXCL10, C-Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human FABP4/A-FABP, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Albumin from human serum Protein
Application:
Reactivity: Human
Conjugate:
Human TGF-Beta 1 / TGFB1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Sorcin/SRI, N-Twin Strep, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human EPCR/PROCR/CD201, C-His, Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CKM, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human GHRL, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human NAMPT, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Myoglobin, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human VEGF-D, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human GDF-15, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human PDGF-B, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human FABP5/E-FABP, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-18, Tag Free (HEK293) Protein
Application:
Reactivity: Human
Conjugate:
Human Fetuin A/AHSG, Tag Freee Protein
Application:
Reactivity: Human
Conjugate:
Human FABP2, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Lipocalin-2/NGAL, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Ficolin-2, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human HAO1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Cardiotrophin-1/CT-1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Antithrombin III, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human HIF-1 alpha/HIF1A, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-6, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human E-Selectin/CD62E, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL-33, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IAPP/Amylin, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human PFKP, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IGF-I R/IGF1R, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL1RL1/DER4/ST2, C-His (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human Pro-neuropeptide Y, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human C-peptide Protein
Application:
Reactivity: Human
Conjugate:
Human Tissue Factor, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Apolipoprotein M/APOM, Tag Free
Application:
Reactivity: Human
Conjugate:
Human Serpin A12, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human SERPING1/C1 inhibitor, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human GLA/alpha-Galactosidase A, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human AGRP, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human ANGPTL4, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Coagulation factor XII/F12, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL1RL1/DER4/ST2, C-hFc, His (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human Peroxiredoxin 6/PRDX6, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
GLP-1 (7-36, amide) peptide
Application:
Reactivity: Human
Conjugate:
Human Caspase-1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human HGF, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human FGF Basic/FGF2, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Autotaxin/ENPP-2, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Serum Amyloid P-component/APCS, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Leptin Receptor, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human ACE2, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human Serpin F1/PEDF, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human FABP3 / H-FABP, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CKMB heterodimer, C-Flag, StrepII Tag&C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Apolipoprotein E/APOE4 (C130R), Tag Free
Application:
Reactivity: Human
Conjugate:
Human HGF, C-Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human tPA, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Angiotensinogen, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Renin, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Transthyretin/TTR, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Apolipoprotein A-I/APOA1, Tag Free
Application:
Reactivity: Human
Conjugate:
Human Apolipoprotein B-100/APOB, Tag Free
Application:
Reactivity: Human
Conjugate:
Human Alpha-fetoprotein, C-His Tag
Application:
Reactivity: Human
Conjugate:
Human Plasminogen/PLG, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Alpha 2 Antiplasmin/SerpinF2, C-HIs Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-18, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-17F, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human G-CSF, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IMMT/Mitofilin, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CASQ2, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human FGF2/b-FGF, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human VEGF121, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human TNF RII/TNFRSF1B, C-His (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IP-10/CXCL10, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human VEGF165, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CALCA, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Periostin/OSF-2, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CCL2/MCP1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Adiponectin/Acrp30, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Beta-2-microglobulin/B2M, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human VE-cadherin, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IGF1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human LILRB4/ILT3, C-His, Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL-6, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human TIE2/TEK, C-His, Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human Pentraxin 3/PTX3, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human A2M/alpha-2-macroglobulin, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Resistin, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human VEGFR2/KDR, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
