Human Caspase-1, Tag Free Protein
Catalog# HA211426
Human Caspase-1, Tag Free Protein
Product Information
Product name
Human Caspase-1, Tag Free Protein
Catalog No.
HA211426
Predicted molecular mass
32.8 kD
Protein construction description
A DNA sequence encoding the human Caspase-1 protein (P29466-1) (Asn 120-His 404) was expressed with tag Free.
Accession
P29466-1
Protein construction
Caspase-1 (120-404)
Source
HEK293
Bio Activity
Testing in progress.
Purity
>95% as determined by SDS-PAGE.
Endotoxin
Less than 1.0 EU per μg by the LAL method.
Formulation
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
Species
Human
Background
Caspase-1, originally designated ICE (for IL-1 converting enzyme), is a member of the group of caspases with large prodomains. Caspase-1 promotes maturation of interleukin IL-1β and interleukin18 (IL-18) by proteolytic cleavage of precursor forms into biologically active pro-inflamatory cytokines. Active caspase-1, a (p20/p10)2 tetramer, is necessary and sufficient for cleavage of precursor IL-1 as well as for induction of apoptosis in some cell lines. The highly conserved family of caspases mediate many of the morphological and biochemical features of apoptosis, including structural dismantling of cell bodies and nuclei, fragmentation of genomic DNA, destruction of regulatory proteins and propagation of other pro-apoptotic molecules. The human Caspase-1 gene maps to chromosome 2q14 and encodes a cytoplasmic protein expressed in liver, heart, skeletal muscle kidney and testis. Caspase-1 has been implicated in inflammation, septic shock, and other situations such as wound healing and the growth of certain leukemias.
Usage guide
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.
Storage
Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
Reconstitution
Reconstitute at 250 μg/ml in sterile water.
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Reactivity: Human
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Reactivity: Human
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Reactivity: Human
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Reactivity: Human
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Reactivity: Human
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Reactivity: Human
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Reactivity: Human
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Reactivity: Human
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Reactivity: Human
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Reactivity: Human
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Reactivity: Human
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Reactivity: Human
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Reactivity: Human
Conjugate:
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Reactivity: Human
Conjugate:
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Reactivity: Human
Conjugate:
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Application:
Reactivity: Human
Conjugate:
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Reactivity: Human
Conjugate:
Human tPA, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Angiotensinogen, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CCL20, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Renin, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human TNF-alpha, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human NG2/MCSP/CSPG4, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL-3R alpha/CD123, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human KLK3, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-7, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CDC42, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human NRG1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Transthyretin/TTR, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Haptoglobin/HP, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human uPAR/PLAUR, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human VEGFR3/FLT4, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human SOD1/Cu-Zn SOD, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Apolipoprotein A-I/APOA1, Tag Free
Application:
Reactivity: Human
Conjugate:
Human IL-13, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CD28, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Mesothelin, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human MAPK12, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IFN-alpha/beta R1, C-His (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CD58/LFA-3, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL-21, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human RAC1, C-Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-31, C-Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human BST2/Tetherin, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CD46, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CD117/c-Kit, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human TACI/TNFRSF13B, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-20, C-hFc Tag Protein
Application:
Reactivity: Human
Conjugate:
Human NKp46/NCR1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human GITR Ligand/TNFSF18, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human APOC3, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human NKG2D, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CCL22 / MDC, C-hFc Tag Protein
Application:
Reactivity: Human
Conjugate:
Human LAP3, C-His Tag (Isoform 2) Protein
Application:
Reactivity: Human
Conjugate:
Human PLGF/PGF, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Ferritin heavy chain 1/FTH1, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CD70/CD27 Ligand/TNFSF7, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Plasminogen/PLG, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human FABP2, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human FGL1, C-hFc Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-2R alpha, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-2RB/CD122, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IFN-gamma, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human 4-1BB/TNFRSF9, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Siglec-7/CD328, C-His (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human RBP4, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human G-CSF, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IMMT/Mitofilin, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CASQ2, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-1 beta/IL1B, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human FGF2/b-FGF, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human MMP-7, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Osteoactivin/GPNMB, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human EGF, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-10, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-4, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CKM, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-2, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human HVEM/TNFRSF14, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human ICAM-1/CD54, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human PDGF-B, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human PD-L1/B7-H1, C-hFc Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-16, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human VEGF121, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human TNF RII/TNFRSF1B, C-His (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human PD-L1/B7-H1, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human B7-H3, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL-29/IFN-lambda 1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Osteoprotegerin / TNFRSF11B, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CD272/BTLA, C-His, Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human HVEM/TNFRSF14, C-Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human MAPK6, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human TOPBP1, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CD5, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human MMP3, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IP-10/CXCL10, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CXCL12/SDF-1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human ACP3/ACPP, C His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CD27/TNFRSF7, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human LILRB1/CD85j/ILT2, C-His, Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human GITR/TNFRSF18/AITR, C-Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human Leptin, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CD2, C-His, Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL-1 alpha/IL1A, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human cIAP-2/BIRC3, N-Twin Strep, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Periostin/OSF-2, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-4R, C-His, Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human NRG1, C-Flag (176-246) Protein
Application:
Reactivity: Human
Conjugate:
Human CXCL9, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CCL2/MCP1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CTLA-4, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CD31/PECAM-1, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human MMP1, C-Flag Protein
Application:
Reactivity: Human
Conjugate:
Human P-Selectin/CD62P, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human Adiponectin/Acrp30, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Beta-2-microglobulin/B2M, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL12B/P40, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human PD-1, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human VCAM-1 / CD106, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human VE-cadherin, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human LILRB4/ILT3, C-His, Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL-18 BPa, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CD63, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CD207, C-Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human ANPEP/CD13, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CXCL1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human ACP1, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human COX5A, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human B7-DC/PD-L2/CD273, C-Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL-6, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-6R, C-His (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human GADD45A, N-Twin Strep, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human TIE2/TEK, C-His, Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human Pentraxin 3/PTX3, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human A2M/alpha-2-macroglobulin, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human MMP-9, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human NCAM1/CD56, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human Fibronectin/FN1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human DPP-4/CD26/DPPIV, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CD14, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CYLD, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL2RG/CD132, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human E-Cadherin, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human TIMP1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human MMP2/CLG4A, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Resistin, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human VEGFR2/KDR, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IFN-gamma R1, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human Interferon alpha-2/IFNA2, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Carbonic Anhydrase XII/CA12, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
