Human Neuropilin-1/NRP1, C-His Tag (ECD) Protein
Active
Catalog# HA211017
Human Neuropilin-1/NRP1, C-His Tag (ECD) Protein
Product Information
Product name
Human Neuropilin-1/NRP1, C-His Tag (ECD) Protein
Catalog No.
HA211017
Predicted molecular mass
71.7 kD
Protein construction description
A DNA sequence encoding the human Neuropilin-1/NRP1 protein (O14786-1) (Phe 22-Lys 644) was expressed with a His tag at the C-terminus.
Accession
O14786-1
Protein construction
Neuropilin-1/NRP1 (22-644)
His
Source
HEK293
Bio Activity
Immobilized Recombinant Human VEGF165, Tag Free(Cat:HA210784) at 2 μg/mL (50 μL/well) can bind Recombinant Human Neuropilin-1/NRP1, C-His Tag (ECD)(Cat:HA211017), the EC50 is 30-120 ng/mL.
Purity
>95% as determined by SDS-PAGE.
Endotoxin
Less than 1.0 EU per μg by the LAL method.
Formulation
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
Species
Human
Background
Neuropilin is a type I transmembrane receptor that has been implicated in aspects of axon growth and guidance and has been shown to act as a high affinity receptor for class III semaphorins and vascular endothelial growth factor (VEGF). A closely related protein, neuropilin-2, shares a common domain structure and signifcant homology with neuropilin and also acts as a receptor for the class III semaphorins and VEGF. Both neuropilins are involved in regulating many physiological pathways including axonal guidance and angiogenesis, however they exhibit differential expression in the adult vasculature. Neuropilin-2 is polysialylated and expressed on the surface of dendritic cells. It is also expressed by venous and lymphatic endothelium. Neuropilin is expressed predominantly by arterial endothelium.
Usage guide
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.
Storage
Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
Reconstitution
Reconstitute at 250 μg/ml in sterile water.
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Human CCL11/Eotaxin, Tag Free Protein
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Human IL-2, C-His Tag Protein
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Human TRAF3, C-His Tag Protein
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Human 5'-nucleotidase/CD73/NT5E, C-His Tag Protein
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Reactivity: Human
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Reactivity: Human
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Reactivity: Human
Conjugate:
Human IL-2RB/CD122, C-His Tag (ECD) Protein
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Reactivity: Human
Conjugate:
Human IFN-gamma, C-His Tag Protein
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Reactivity: Human
Conjugate:
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Reactivity: Human
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Reactivity: Human
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Human IL-1 beta/IL1B, C-His Tag Protein
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Reactivity: Human
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Reactivity: Human
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Human IL-10, C-His Tag Protein
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Reactivity: Human
Conjugate:
Human IL-4, Tag Free Protein
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Reactivity: Human
Conjugate:
Human IL-2, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human HVEM/TNFRSF14, Tag Free (ECD) Protein
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Reactivity: Human
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Human ICAM-1/CD54, C-His Tag (ECD) Protein
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Reactivity: Human
Conjugate:
Human PD-L1/B7-H1, C-hFc Tag Protein
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Reactivity: Human
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Human IL-16, C-His Tag Protein
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Reactivity: Human
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Human TNF RII/TNFRSF1B, C-His (ECD) Protein
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Reactivity: Human
Conjugate:
Human PD-L1/B7-H1, C-His Tag Protein
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Reactivity: Human
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Human B7-H3, C-His Tag (ECD) Protein
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Reactivity: Human
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Reactivity: Human
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Reactivity: Human
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Reactivity: Human
Conjugate:
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Reactivity: Human
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Reactivity: Human
Conjugate:
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Application:
Reactivity: Human
Conjugate:
Human CCL2/MCP1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CTLA-4, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CD31/PECAM-1, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human P-Selectin/CD62P, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL12B/P40, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human PD-1, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human VCAM-1 / CD106, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human VE-cadherin, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human LILRB4/ILT3, C-His, Flag Tag (ECD) Protein
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Reactivity: Human
Conjugate:
Human IL-18 BPa, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CD63, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CD207, C-Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human ANPEP/CD13, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CXCL1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human B7-DC/PD-L2/CD273, C-Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL-6, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-6R, C-His (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human GADD45A, N-Twin Strep, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human TIE2/TEK, C-His, Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human NCAM1/CD56, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human DPP-4/CD26/DPPIV, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CD14, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CYLD, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL2RG/CD132, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human E-Cadherin, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human TIMP1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human VEGFR2/KDR, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IFN-gamma R1, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
