Human Integrin beta 1 / ITGB1, C-Strep II Tag Protein

Usd: 129 Special Discount

Specification

20μg

50μg

100μg

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Catalog# HA211609

Human Integrin beta 1 / ITGB1, C-Strep II Tag Protein

Product Information

Product name

Human Integrin beta 1 / ITGB1, C-Strep II Tag Protein

Catalog No.

HA211609

Predicted molecular mass

80.6 kD

Protein construction description

A DNA sequence encoding the human Integrin beta 1 / ITGB1 protein (P05556-1) (Gln 21-Asp 728) was expressed with a Strep II tag at the C-terminus.

Accession

P05556-1

Protein construction

Integrin beta 1 / ITGB1 (21-728) Strep II

Source

HEK293

Bio Activity

Testing in progress.

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.

Species

Human

Background

Integrin beta-1 (ITGB1), also known as CD29, is a cell surface receptor that in humans is encoded by the ITGB1 gene. This integrin associates with integrin alpha 1 and integrin alpha 2 to form integrin complexes which function as collagen receptors. It also forms dimers with integrin alpha 3 to form integrin receptors for netrin 1 and reelin. These and other integrin beta 1 complexes have been historically known as very late activation (VLA) antigens. Integrin beta 1 is expressed as at least four different isoforms. In cardiac muscle and skeletal muscle, the integrin beta-1D isoform is specifically expressed, and localizes to costameres, where it aids in the lateral force transmission from the Z-discs to the extracellular matrix. Abnormal levels of integrin beta-1D have been found in limb girdle muscular dystrophy and polyneuropathy.

Usage guide

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.

Storage

Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.