Human Agrin, C-His Tag Protein
Catalog# HA211173
Human Agrin, C-His Tag Protein
Product Information
Product name
Human Agrin, C-His Tag Protein
Catalog No.
HA211173
Predicted molecular mass
104.4 kD
Protein construction description
A DNA sequence encoding the human Agrin protein (O00468) (Ala 1103-Pro 2068) was expressed with a His tag at the C-terminus.
Accession
O00468
Protein construction
Source
HEK293
Bio Activity
Testing in progress.
Purity
>90% as determined by SDS-PAGE.
Endotoxin
Less than 1.0 EU per μg by the LAL method.
Formulation
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
Species
Human
Background
This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found. Alternative splicing results in multiple transcript variants encoding different isoforms.
Usage guide
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.
Storage
Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
Reconstitution
Reconstitute at 250 μg/ml in sterile water.
Citation
-
The protective role of Agrin and CAF22 in hypertensive nephropathy
Journal: International Immunopharmacology
DOI: 10.1016/j.intimp.2025.115107
IF: 4.7
Application: WB
Reactivity: Mouse
Publish date: 2025 Jun
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