Human MAPK1/ERK2, C-His Tag Protein
Catalog# HA211598
Human MAPK1/ERK2, C-His Tag Protein
Product Information
Product name
Human MAPK1/ERK2, C-His Tag Protein
Catalog No.
HA211598
Predicted molecular mass
43.8 kD
Protein construction description
A DNA sequence encoding the human MAPK1/ERK2 protein (P28482-1) (Met 1 -Ser 360) was expressed with a His tag at the C-terminus.
Accession
P28482-1
Protein construction
MAPK1/ERK2 (1-360)
His
Source
E.coli
Bio Activity
Testing in progress.
Purity
>95% as determined by SDS-PAGE.
Endotoxin
Less than 1.0 EU per μg by the LAL method.
Formulation
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
Species
Human
Background
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis.
Usage guide
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.
Storage
Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
Reconstitution
Reconstitute at 250 μg/ml in sterile water.
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Reactivity: Human
Conjugate:
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Reactivity: Human
Conjugate:
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Reactivity: Human
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Reactivity: Human
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Reactivity: Human
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Reactivity: Human
Conjugate:
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Reactivity: Human
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Reactivity: Human
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Reactivity: Human
Conjugate:
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Reactivity: Human
Conjugate:
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Reactivity: Human
Conjugate:
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Reactivity: Human
Conjugate:
Human Caspase-9/CASP9, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IFNB1/IFN beta, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CD44, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CD2, N-Twin Strep, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CD40/TNFRSF5, C-His Tag Protein
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Reactivity: Human
Conjugate:
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Reactivity: Human
Conjugate:
Human Kininogen 1, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human HVEM/TNFRSF14, Tag Free (ECD) Protein
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Reactivity: Human
Conjugate:
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Application:
Reactivity: Human
Conjugate:
Human MRC1/CD206, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
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Application:
Reactivity: Human
Conjugate:
Human beta-NGF, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CCL21/6Ckine, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human NT-proBNP, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Osteopontin/OPN, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human LAIR1, N-Twin Strep, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Pro-Collagen I alpha 1/COL1A1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Tau/Tau441 (1-256 Fragment), Tag Free (isoform 2N4R) Protein
Application:
Reactivity: Human
Conjugate:
Human CD48, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human TNNI3, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human BACE1, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human TLR3, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human ATF6, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CXCL5, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CD14, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IKK gamma/NEMO, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human FGF Basic/FGF2, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human APP, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human TAG1/Contactin 2/CNTN2, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CEACAM-6/CD66c, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human c-Fos, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human ICOS Ligand/B7-H2/ICOSLG, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CSK, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human GLP1R, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human LAMP3/CD208, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CDCP1/CD318, N-Twin Strep, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human PRDM1, N-Twin Strep, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human ULBP1/NKG2DL1, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Endoglin/CD105, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human Leptin Receptor, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human Beta-NGF, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human OSMR, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human BAFF/TNFSF13B/CD257 Trimer design, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CD47, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human DVL2, C Twin Strep, Flag Protein
Application:
Reactivity: Human
Conjugate:
Human 5'-nucleotidase/CD73/NT5E, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human GADD45B, N-Twin Strep, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CD40 Ligand/TNFSF5, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human ABL1/JTK7/p150, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CD147/Basigin/EMMPRIN, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Apolipoprotein E/APOE4 (C130R), Tag Free
Application:
Reactivity: Human
Conjugate:
Human IL-10, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human HGF, C-Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human B7-1/CD80, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CCL5/RANTES, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CCL26/Eotaxin-3, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human 14-3-3 zeta, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CCL20, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human TNF-alpha, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human DKK1, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-3R alpha/CD123, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-7, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CDC42, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human NRG1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human EPHA2, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human FGF1, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human uPAR/PLAUR, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human VEGFR3/FLT4, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-13, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CD28, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human TGF-beta RII, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human MAPK12, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IFN-alpha/beta R1, C-His (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CD58/LFA-3, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL-21, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human RAC1, C-Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-31, C-Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Flt3 Ligand/FLT3LG, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human BST2/Tetherin, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CD46, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CD117/c-Kit, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-18 R1 / CD218a, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-20, C-hFc Tag Protein
Application:
Reactivity: Human
Conjugate:
Human 14-3-3 gamma/YWHAG, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CCL22 / MDC, C-hFc Tag Protein
Application:
Reactivity: Human
Conjugate:
Human COL1A2, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human VEGFR1/FLT1 C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CD21/CR2, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-18, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CCL3/MIP-1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL12RB1, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human POMC, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-1 beta/IL1B, Tag Free (pro form) Protein
Application:
Reactivity: Human
Conjugate:
Human IL-2R alpha, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-2RB/CD122, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IFN-gamma, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human 4-1BB/TNFRSF9, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Siglec-7/CD328, C-His (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL-17F, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human Oxytocin/OXT, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human G-CSF, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human alpha-Synuclein, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CRKL, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human FGF2/b-FGF, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IGFBP3/IBP3, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human EGF, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-10, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-2, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human ICAM-1/CD54, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human PD-L1/B7-H1, C-hFc Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-16, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human VEGF121, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human TNF RII/TNFRSF1B, C-His (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human B7-H3, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human HCLS1, N-Strep II, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human KIF5B, N-Twin Strep, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CD272/BTLA, C-His, Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human HVEM/TNFRSF14, C-Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human MAPK6, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human MAP4K1/HPK1, N-Twin Strep, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human FGF7, C-Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IP-10/CXCL10, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CXCL12/SDF-1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL-1 RII, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CD27/TNFRSF7, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human VEGF165, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human PPID, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human LILRB1/CD85j/ILT2, C-His, Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human GITR/TNFRSF18/AITR, C-Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CEACAM-1/CD66a, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CD200, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CD2, C-His, Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL-1 alpha/IL1A, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-4R, C-His, Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human NRG1, C-Flag (176-246) Protein
Application:
Reactivity: Human
Conjugate:
Human CXCL9, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CCL2/MCP1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CTLA-4, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CD31/PECAM-1, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human P-Selectin/CD62P, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human Adiponectin/Acrp30, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL12B/P40, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human PD-1, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Tau/Tau441, C-His (isoform 2N4R) Protein
Application:
Reactivity: Human
Conjugate:
Human VCAM-1 / CD106, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human VE-cadherin, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IGF1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human LILRB4/ILT3, C-His, Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL-18 BPa, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CD63, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CD207, C-Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human ANPEP/CD13, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human CXCL1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human COX5A, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human B7-DC/PD-L2/CD273, C-Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IL-6, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human IL-6R, C-His (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human GADD45A, N-Twin Strep, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
Human TIE2/TEK, C-His, Flag Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human NCAM1/CD56, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human Fibronectin/FN1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human GH1, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human DPP-4/CD26/DPPIV, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human PDGF-AA, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CD14, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human CYLD, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human FGF7, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human IL2RG/CD132, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human E-Cadherin, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human TIMP1, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human VEGFR2/KDR, Tag Free (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human IFN-gamma R1, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human Interferon alpha-2/IFNA2, C-His Tag Protein
Application:
Reactivity: Human
Conjugate:
Human Prolactin/PRL, C-His, Flag Tag Protein
Application:
Reactivity: Human
Conjugate:
