Human IL-12 / IL-23 p40 ELISA Kit(EH0072)

UNIPROT #

P29459/P29460/Q9NPF7

PROTEIN NAME

IL-12 / IL-23 p40

SYNONYMS

Interleukin-12 subunit alpha IL-12A Cytotoxic lymphocyte maturation factor 35 kDa subunit (CLMF p35) IL-12 subunit p35 NK cell stimulatory factor chain 1 (NKSF1) IL12A NKSF1 Interleukin-12 subunit beta IL-12B Cytotoxic lymphocyte maturation factor 40 kDa subunit (CLMF p40) IL-12 subunit p40 NK cell stimulatory factor chain 2 (NKSF2) IL12B NKSF2 Interleukin-23 subunit alpha IL-23 subunit alpha IL-23-A Interleukin-23 subunit p19 (IL-23p19) IL23A SGRF UNQ2498 PRO5798

FUNCTION

Interleukin 12 (IL-12), also known as natural killer cell stimulatory factor (NKSF) or cytotoxic lymphocyte maturation factor (CLMF), is a heterodimeric pleiotropic cytokine made up of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit. The IL-12 p40 subunit is shared by IL-23, another heterodimeric cytokine that has biological activities similar to, as well as distinct from, IL-12. IL-12 is produced by macrophages and B cells and has been shown to have multiple effects on T cells and natural killer (NK) cells. While mouse IL-12 is active on both human and mouse cells, human IL-12 is not active on mouse cells.