Human IL-17A ELISA Kit ( EH0004)

UNIPROT #

Q16552

PROTEIN NAME

IL-17A

FUNCTION

Interleukin‑17A (IL‑17A), also known as CTLA‑8, is a 15‑20 kDa glycosylated cytokine that plays an important role in anti‑microbial and chronic inflammation. The six IL‑17 cytokines (IL‑17A‑F) are encoded by separate genes but adopt a conserved cystine knot fold. Mature human IL‑17A shares 60% amino acid sequence identity with mouse and rat IL‑17A. IL‑17A is secreted by Th17 cells, gamma /δ T cells, iNKT cells, NK cells, LTi cells, neutrophils, and intestinal Paneth cells. It forms disulfide‑linked homodimers as well as disulfide‑linked heterodimers with IL‑17F. IL‑17A exerts its effects through the transmembrane IL‑17 RA in complex with IL‑17 RC or IL‑17 RD. Both IL‑17 RA and IL‑17 RC are required for responsiveness to heterodimeric IL‑17A/F. IL‑17A promotes protective mucosal and epidermal inflammation in response to microbial infection. It induces chemokine production, neutrophil influx, and the production of antibacterial peptides. IL‑17A/F likewise induces neutrophil migration, but IL‑17F does not. IL‑17A additionally enhances the production of inflammatory mediators by rheumatoid synovial fibroblasts and contributes to TNF‑ alpha induced shock. In contrast, it can protect against the progression of colitis by limiting chronic inflammation. IL‑17A encourages the formation of autoreactive germinal centers and exacerbates the onset and progression of experimental models of autoimmunity. IL‑17A has been shown to exert either tumorigenic or anti‑tumor effects.